| 脂肪酸合成酶在食管癌中的表达及其对食管癌细胞增殖的影响 |
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| 引用本文： | 周永莉,牛春燕,高保华,李艳东.脂肪酸合成酶在食管癌中的表达及其对食管癌细胞增殖的影响[J].山西医学院学报,2014(2):98-100,163. |
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| 作者姓名： | 周永莉 牛春燕 高保华 李艳东 |
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| 作者单位： | [1]西安医学院附属医院消化内科,西安710077 [2]西安医学院附属医院病理科,西安710077 |
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| 基金项目： | 陕西省教育厅科研计划基金资助项目（11JK0706） |
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| 摘 要： | 目的 探讨脂肪酸合成酶（FAS）在食管癌中的表达及其对食管癌细胞增殖的影响. 方法 应用免疫组织化学的方法检测60例食管鳞状细胞癌中FAS的表达情况,MTT、FCM及Tunel检测脂肪酸合成酶抑制剂C75作用后食管癌细胞的增殖及凋亡情况. 结果 脂肪酸合成酶在食管鳞状细胞癌中过表达,95.0％的食管鳞状细胞癌表达FAS,而正常食管黏膜不表达FAS.应用C75后食管癌细胞TE13的增殖得到抑制,并能够诱导凋亡. 结论 脂肪酸合成酶在食管鳞状细胞癌中过表达,并能够促进细胞增殖.可能在食管癌的发生发展中起到重要作用,并成为食管癌治疗的新靶点.
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| 关 键 词： | 脂肪酸合成酶 C75 增殖 凋亡 |
Expression of FAS in esophageal cancer and its effects on proliferation of TE13 cells |
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| Authors: | ZHOU Yongli NIU Chunyan GAO Baohua LI Yandong |
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| Institution: | 1.Department of Gastroenterology,Affiliated Hospital,Xi＇an Medical University ,Xi＇an 710077, China; 2.Department of Pathology,Affiliated Hospital, Xi＇an Medical University;) |
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| Abstract: | Objective To investigate the expression of FAS in esophageal cancer and to explore its relationship with squamous carcinoma cell proliferation.Methods The expression of FAS in esophageal cancer was measured by immnohistochemistry.The effects of C75 on cell proliferation and apoptosis were determined by MTT,FCM and TUNEL,respectively.Results The positive rate of FAS in esophageal squamous cell cancer was 95.0％.However,all cases of normal esophageal epithelium did not express the FAS.The C75 inhibited the cell proliferation and increased the apoptosis of TE13.Conclusion FAS is overexpressed in esophageal squamous cell cancer tissues,and could enhance the proliferation of esophageal squamous carcinoma cell.FAS may be involved in the esophageal cancer progression,and considered as a therapeutic target for the esophageal cancer. |
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| Keywords: | fatty acid synthase C75 cell proliferation apoptosis |
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