Endurance training enhances ABCA1 expression in rat small intestine |
| |
Authors: | Behzad Mehdi Khabazian Abbass Ghanbari-Niaki Ali reza Safarzadeh-Golpordesari Mehdi Ebrahimi Fatemeh Rahbarizadeh and Hossein Abednazari |
| |
Institution: | (1) Department of Exercise Physiology, Faculty of Physical Education and Sports Sciences, University of Tehran, Tehran, Iran;(2) Department of Physical Education and Sports Sciences, Faculty of Physical Education and Sports Sciences, University of Mazandaran, Babolsar, Iran;(3) Department of Physical Education and Sports Sciences, Faculty of Humanity, Tarbiat Modares University, Tehran, Iran;(4) Department of Biotechnology, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran;(5) Faculty of Physical Education and Sports Science, Tarbiat Moallem University, Tehran, Iran |
| |
Abstract: | The purpose of this study was to investigate liver and intestinal ABCA1 expression and plasma HDL-C level in response to treadmill-running
training in rats. Twenty adult Wistar male rats (17–18 weeks old, 300–322 g) were divided into control (n = 10) and Training (n = 10) groups. Training group trained at 25 m/min (0% grade) for 60 min/day, 5 days/week for 12 weeks. Rats were killed 48 h
after the last session of training. The intestinal and liver ABCA1 mRNA expression was found to be significantly higher in
trained compared to control group (P < 0.006 and P < 0.024, respectively). Intestine and liver ATP concentrations remained unchanged. Plasma HDL-C, HDL2-C, Apo A-1, pre-β HDL-C
concentration, LCAT activity, TC/HDL-C and LDL-C/HDL-C ratio significantly increased in trained group (P < 0.01, P < 0.006, P < 0.001, P < 0.001 P < 0.067, P < 0.02, and P < 0.03, respectively). However, other lipoprotein concentrations were unchanged. In conclusion, we found that endurance training
induced significant elevation in plasma HDL-C and HDL2-C concentrations, accompanied by higher plasma Apo A-1, pre-β HDL-C
concentrations, LCAT activity and ABCA1 mRNA expressions in rat intestine, and liver. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|