| 新藤黄酸脂质体冻干粉的制备及其包封率测定 |
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| 引用本文： | 方玲,孟楣,夏伦祝,王效山,彭代银.新藤黄酸脂质体冻干粉的制备及其包封率测定[J].安徽医药,2009,13(6):596-598. |
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| 作者姓名： | 方玲 孟楣 夏伦祝 王效山 彭代银 |
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| 作者单位： | 安徽中医学院药学院,安徽,合肥,230061;安徽省中药研究和开发重点实验室,安徽,合肥,230061;安徽中医学院第一附属医院药学部,安徽,合肥,230031 |
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| 摘 要： | 目的制备新藤黄酸脂质体冻干粉并测定其包封率。方法采用薄膜-超声法结合冷冻干燥法制备新藤黄酸脂质体冻干粉,以冷冻超速离心-高效液相色谱法测定包封率。结果电镜下观察所制备的脂质体形态规整,平均粒径为128.30 nm,包封率为83.74%。结论此法制备了包封率较高的新藤黄酸冻干脂质体。
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| 关 键 词： | 新藤黄酸 脂质体 冷冻干燥 包封率 |
Preparation of Neo-gambogic lyophilized liposomes and determination of its encapsulation efficiency |
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| FANG Ling,MENG Mei,XIA Lun-zhu,WANG Xiao-shan,PENG Dai-yin.Preparation of Neo-gambogic lyophilized liposomes and determination of its encapsulation efficiency[J].Anhui Medical and Pharmaceutical Journal,2009,13(6):596-598. |
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| Authors: | FANG Ling MENG Mei XIA Lun-zhu WANG Xiao-shan PENG Dai-yin |
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| Institution: | FANG Ling1,3,MENG Mei2,XIA Lun-zhu2,WANG Xiao-shan1,PENG Dai-yin1,3(1.Anhui College of TCM,Hefei 230061,2.First Affiliated Hospital of Anhui College of TCM,Hefei 230031,3.Key Laboratory of Chinese medicine research , development in Anhui province,Hefei 230061) |
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| Abstract: | Aim To prepare Neo-gambogic lyophilized Liposomes and to develop a method for determining its entrapment efficiency.Methods Liposomes were prepared by rotary-evaporated film-ultrasonication method;and then further treated with lyophilization.Free GNA and liposomes were separated by ultracentrifugation and HPLC was applied to determine the encapsulation efficiency.Results GNA liposomes were uniform and spheric;its mean particle size was 128.30 nm;the encapsulation efficiency was 83.74%.Conclusion The present... |
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| Keywords: | neo-gambogic liposome lyophilization encapsulation efficiency |
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