新发现的HIV/AIDS患者T淋巴细胞亚群的特点及临床意义

目的分析新发现的HIV感染者和AIDS患者T淋巴细胞亚群定量检测结果,了解HIV/AIDS患者的免疫状况.方法回顾性分析昆明医科大学第一附属医院2009年1月至2011年12月新发现的115例HIV/AIDS患者的首次T淋巴细胞亚群定量检测结果,包括CD3+CD4+、CD3+CD8+绝对值及CD4+/CD8+的比值.结果 T淋巴细胞亚群定量检测结果均值:CD3+CD4+为(229±215)个/μL,CD3+CD8+为(919±756)个/μL,CD4+/CD8+为(0.27±0.21)个/μL.有87例(75.7%)患者的CD4+T淋巴细胞<350个/μL,有62例(53.9%)患者的CD4+T淋巴细胞<200个/μL,其中有33例患者(28.7%)CD4+T淋巴细胞<50个/μL.不同性别、年龄组在T淋巴细胞亚群分布结果上无显著性差异(P>0.05).结论 T淋巴细胞亚群定量检测结果能反映HIV/AIDS患者的免疫受损情况及疾病的严重程度,对选择合适的干预措施具有重要的临床意义.

Characteristics and Clinical Significance of T Lymphocyte Subsets in Newfound HIN/AIDS Patients

Objective To detect T lymphocyte subsets in newfound HIV/AIDS patients and find out immunological status of HIV/AIDS patients.Methods The subjects were the newfound 115 patients with HIV infection/AIDS from 2009 to 2011,and retrospective analysis was done in the consequence of T lymphocyte subsets detection,including the absolute number of CD3+CD4+ lymphocytes,CD3+CD8+lymphocytes and ratio of CD3+CD4+/CD3+CD8+.Results The mean value of absolute number of T lymphocyte:CD3+CD4+T lymphocyte was(229±215)/μL,CD3+CD8+T lymphocyte was(919±756)/μL,ratio of CD3+CD4+/CD3+CD8+was 0.27±0.21.There were 87(75.7%)patients,whose CD4+T lymphocyte was < 350/μL,62(53.9%)patients’ CD4+ T lymphocyte was < 200/μL,33(28.7%)patients’ CD4+ T lymphocyte was < 200/μL.The T lymphocyte subsets of patients with different gender and age had no distinct difference.Conclusion The consequence of T lymphocyte subsets detection could reflect the immune deficiency and severity of the disease,and has important clinical significance for seleting suitable intervention measure.