佤族人群CCR5基因59029G/A多态性与糖尿病前期和糖尿病的相关性研究

目的 探讨CC类趋化因子受体5(CCR5)基因启动子区59029G/A多态性与云南省临沧市沧源佤族人群糖尿病前期(PD)及糖尿病(DM)的相关性.方法 运用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术检测73例PD,36例DM患者和60例健康对照者(NC)的CCR5基因59029G/A多态性.比较分析各组间基因型和等位基因频率以及相关临床资料.结果 (1)佤族PD组、DM组和NC组间的基因型和等位基因频率无统计学意义(P＞0.05); (2)腹型肥胖和年龄可能是PD和DM发生的危险因素,高血压和血胆固醇(TC)可能是PD发生的危险因素(P＜0.05).结论 CCR5基因59029G/A多态性可能不是佤族人群PD及DM发生的遗传危险因素;改善生活方式,减少高血压和腹型肥胖的发生町能会减少PD和DM的发生.

Association of the 59029G/A Polymorphism of CCR5 Gene and Pre-diabetes,Diabetes Mellitus in Wa People

Objective To explore the association of the 59029G/A polymorphism of CCR5 gene with Pre-diabetes and Diabetes mellitus in Wa People.Methods The genetype was detected by PCR-RFLP in 73 Wa people with pre-diabetes(PD),36 Wa peopl with Diabetes mellitus(DM)and 60 healthy Wa people as normol controls(NC).The genotype and allele frequencies and relative clinic data were compared among groups,then recruit in the survey by questionnaire.Results(1)There was no statistically significant differences in genotypes and allele frequencies distributions among the three groups(P>0.05).(2)Abdominal obesity and age were risk factors of PD and DM development,hypertension and total cholesterol(TC)were risk factors of PD development in Wa people.Conclusions The 59029G/A polymorphism of CCR5 may not be genetic risk factors for PD and DM in Wa People.To improve lifestyle,reduce high blood pressure and abdominal obesity may reduce the occurrence of PD and DM.