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| 云南省部分HIV感染者唾液EBV检出率分析 | |
| 引用本文： | 史会萍,李榕,段开文,夏志刚,高辉,李承文. 云南省部分HIV感染者唾液EBV检出率分析[J]. 昆明医学院学报, 2012, 33(6): 144-146,160 |
| 作者姓名： | 史会萍 李榕 段开文 夏志刚 高辉 李承文 |
| 作者单位： | 1. 昆明医科大学附属延安医院,昆明市延安医院口腔科,云南,昆明,650051 2. 昆明市延安医院检验科,云南,昆明,650051 3. 昆明医科大学第三附属医院,云南省肿瘤医院科研科,云南,昆明,650118 |
| 基金项目： | 国家自然科学基金资助项目，云南省应用基础研究基金资助项目 |
| 摘 要： | 目的探讨HIV感染者唾液EB病毒存在情况及其与免疫抑制的关系.方法采用横断面研究,利用巢氏PCR方法对245例HIV感染者和30例健康对照者唾液EBV DNA的存在情况进行检测,并分析检出率与CD4淋巴细胞计数的关系.结果 HIV感染者和健康对照人群唾液EBV检出率分别为82.0%与30.0%,二者有统计学差异(P<0.05);CD4淋巴细胞计数小于200、200～400和大于400个/μL的患者唾液EBV检出率分别为93.0%、75.8%和45.7%,3组间检出率有显著差异(P<0.05);但是否使用高效抗逆转录病毒治疗对唾液EBV的检出率无明显影响.结论 HIV感染者唾液中EB病毒检出率高,与免疫指标CD4淋巴细胞计数水平有关. |
| 关 键 词： | EB病毒 唾液 聚合酶链反应 人类免疫缺陷病毒 |
Detection of Epstein-Barr Virus in the saliva of human Immunodeficiency Virus Infected Patients from Yunnan Province,China |
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| SHI Hui-ping , LI Rong , DUAN Kai-wen , XIA Zhi-gang , GAO Hui , LI Cheng-wen. Detection of Epstein-Barr Virus in the saliva of human Immunodeficiency Virus Infected Patients from Yunnan Province,China[J]. Journal of Kunming Medical College, 2012, 33(6): 144-146,160 | |
| Authors: | SHI Hui-ping LI Rong DUAN Kai-wen XIA Zhi-gang GAO Hui LI Cheng-wen |
| Affiliation: | 1)Dept.of Dentistry;2)Dept.of Laboratory Medicine,Yan’an Hospital Affiliated to Kunming Medical University,Kunming Yunnan 650051;3)Dept.of Research Management,The 3rd Affiliated Hospital of Kunming Medical University,Yunnan Tumor Hospital,Kunming Yunnan 650118,China) |
| Abstract: | Objective To determine the presence of Epstein-Barr virus(EBV)-DNA in the saliva from human immunodeficiency virus(HIV)-infected individuals and healthy controls from Yunnan.Methods A cross-sectional study was performed in 245 HIV-infected subjects and 30 healthy controls.EBV DNA in saliva samples was examined by nested polymerase chain reaction(PCR).Chi-square test was performed to determine the prevalence rates among groups.Results The detection rate of EBV in HIV-infected group and non-HIV controls were 82.0% and 30.0%,respectively.EBV detection rate in HIV-infected subjects were significantly higher than non-HIV controls(P<0.05).The detection rate of EBV in patients with CD4 counts less than 200 cells/uL,200-400 cells/ul and above 400 cells/ul were 93.0%,75.8% and 45.7%,There was a significant difference among them(P<0.05).No significant difference was observed between the groups HIV-infected subjects who were on HAART and not on HAART(P>0.05).Conclusion The detection rate of oral EBV in HIV is significantly higher in HIV-infected subjects than non-HIV controls,and it is related to CD4 cell level. |
| Keywords: | Saliva Epstein-Barr virus Polymerase chain reaction Human immunodeficiency virus |
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