益生菌治疗婴儿抗生素相关性腹泻疗效分析

目的探讨婴儿抗生素相关性腹泻使用益生菌(微生态制剂)酪酸梭菌活菌散剂(宝乐安)联合消旋卡多曲(Racecadotril Granules,乐度)治疗的效果.方法将120例按入选标准入选的抗生素相关性腹泻1～12月内的婴儿,随机分为2组;治疗组予口服酪酸梭菌活菌散剂(宝乐安)联合消旋卡多曲(乐度);对照组口服消旋卡多曲,72 h后判断疗效.结果治疗组有效57例,无效3例,总有效率95%;对照组有效37例,无效23例,总有效率61.7%;治疗组与对照组临床疗效比较,经采用χ2检验,有统计学意义(P<0.05).结论治疗组无论在大便性状及大便次数改善和全身症状好转方面,均优于对照组;故宝乐安治疗婴儿抗生素相关性腹泻在临床上值得推广.

Efficacy of Probiotics on Antibiotic Associated Infant Diarrhea

Objective To investigate the effect of using Clostridium butyricum viable probiotics powder(Bao le an)and Racecadotril Granules(Le du)together on infant antibiotic-associated diarrhea,and thereby to provide clinical treatment experience.Methods 120 infants aged 1 to 12 months and suffered from antibiotic-associated diarrhea were selected according to criteria,and were randomly divided into 2 groups.Infants in the treatment group orally took Clostridium butyricum viable probiotics powder(Bao le an)together with Racecadotril Granules(Le du).The treatment group received oral Clostridium butyricum powder(PO lean)combined with racecadotril(Music Degree);the control group was treated with racecadotril,72 hours after judging curative effect.Results Clostridium butyricum viable probiotics powder(Po Le’an) together with Racecadotril Granules(Le du) was effective to 57 infants and ineffective to3 infants in the treatment group;the effectiveness rate was 95%.Only using Clostridium butyricum viable probiotics powder(Bao le an)was effective to 37 infants and ineffective to 23 infants in the control group;the effectiveness rate was 61.7%.Comparison of clinical efficacy between treatment group and control group are statistically analysed using χ2 test,P<0.05,the difference was statistically significant.Conclusions The improvement of the stool testure,stool frequency and symptoms of the treatment group is better than that of the control group.Therefore,Clostridium butyricum viable probiotics powder(Bao le an)and Racecadotril Granules(Le du) using together is clinically worth promoting to treat infant antibiotic-associated diarrhea.