| VEGF-C的表达与口腔鳞癌淋巴结转移的关系 |
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| 引用本文： | 冯正虎,李春青,张晓慧,杨兰,刘金英. VEGF-C的表达与口腔鳞癌淋巴结转移的关系[J]. 口腔颌面外科杂志, 2012, 22(2): 89-91 |
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| 作者姓名： | 冯正虎 李春青 张晓慧 杨兰 刘金英 |
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| 作者单位： | 1. 西北民族大学医学院口腔教研室·口腔医学国家民委重点实验室,甘肃兰州730030
2. 兰州大学第二医院口腔颌面外科,甘肃兰州,730030 |
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| 摘 要： | 目的:观察口腔鳞癌中D2-40及VEGF-C的表达特点,探讨VEGF-C在肿瘤淋巴管生成及淋巴结转移中的作用。方法:将43例口腔鳞癌分为淋巴结转移组和无淋巴结转移组,应用免疫组织化学SP法检测D2-40及VEGF-C的表达情况。结果:口腔鳞癌中的淋巴管主要分布在肿瘤边缘区(肿瘤间质)。癌组织中淋巴管密度及VEGF-C的阳性表达率显著高于正常组织(P<0.05),淋巴结转移组癌灶中淋巴管密度及VEGF-C的阳性表达率显著高于无淋巴结转移组(P<0.05)。结论:口腔鳞癌肿瘤边缘区淋巴管与淋巴结转移相关,VEGF-C可能参与口腔鳞癌淋巴管的形成。
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| 关 键 词： | 口腔鳞癌 淋巴管密度 D2-40 VEGF-C 免疫组织化学 |
Expression of D2-40 and VEGF-C and Lymph Node Metastasis in Oral Squamous Cell Carcinoma |
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| FENG Zheng-hu , LI Chun-qing , ZHANG Xiao-hui , YANG Lan , LIU Jin-ying. Expression of D2-40 and VEGF-C and Lymph Node Metastasis in Oral Squamous Cell Carcinoma[J]. Chinese Journal of Oral and Maxillofacial Surgery, 2012, 22(2): 89-91 |
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| Authors: | FENG Zheng-hu LI Chun-qing ZHANG Xiao-hui YANG Lan LIU Jin-ying |
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| Affiliation: | 1(1.Department of Stomatology·Key Laboratory of Stomatology of State Ethnic Affairs Commission,Medical College of Northwest University for Nationalities,Lanzhou 730030,Gansu Province; 2.Department of Oral and Maxillofacial Surgery,the Second Hospital, Lanzhou University,Lanzhou 730030,Gansu Province,China) |
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| Abstract: | Objective: The purpose of this study was to investigate whether the expression of vascular endothelial growth factor C(VEGF-C) and D2-40 are related to metastatic behavior of oral squamous cell carcinoma(OSCC).Methods: A retrospective review of 43 cases with OSCC were conducted.The cases were separated into metastasis group and non-metastasis group,in addition,10 specimen of normal oral mucosa were used as control.D2-40 and VEGF-C expression were detected by immunohistochemistry.Results: Lymphatic vessels in OSCC mainly distributed in the tumor periphery.The expression of lymphatic vessel density(LVD) and VEGF-C in OSCC were significantly higher than those in normal tissue(P<0.05),and they were significantly higher in lymph node metastasis group than in non-metastatic group(P<0.05).Conclusion: The peri-tumoral lymphatic vessels are associated with lymph node metastasis and VEGF-C may related to the generation of lymphatic vessels in OSCC. |
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| Keywords: | oral squamous cell carcinoma(OSCC) lymphatic vessel density(LVD) D2-40 VEGF-C immunohistochemistry |
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