| Blocking effects of phentolamine on L-type calcium current and ATP-sensitive potassium current in guinea pig ventricular myocytes |
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| 引用本文： | 梁勇,吴博威,顿文. Blocking effects of phentolamine on L-type calcium current and ATP-sensitive potassium current in guinea pig ventricular myocytes[J]. Acta pharmacologica Sinica, 1998, 0(2) |
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| 作者姓名： | 梁勇 吴博威 顿文 |
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| 作者单位： | 山西医科大学生理教研室 |
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| 摘 要： | 目的：研究酚妥拉明对豚鼠心室肌细胞Ｌ型钙电流及ＡＴＰ敏感钾电流的作用．方法：用膜片钳的全细胞记录方式观察钙电流和ＡＴＰ敏感钾电流．结果：酚妥拉明５，２５和１００μｍｏｌ·Ｌ－１对钙电流呈浓度依赖性和非电压依赖性的抑制作用，抑制率分别为１７％，２３％和３０％，而对电流电压关系没有影响．这一抑制作用与酚妥拉明对α１和α２受体的作用无关．酚妥拉明１００μｍｏｌ·Ｌ－１可显著抑制ＤＮＰ诱导产生的ＡＴＰ敏感钾电流，抑制率为７５％．结论：酚妥拉明显著抑制豚鼠心室肌细胞Ｌ型钙电流和ＡＴＰ敏感钾电流．
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| 关 键 词： | 酚妥拉明；哌唑嗪；育亨宾；格列本脲；膜片箝技术；钙通道；钾通道；心肌 |
Blocking effects of phentolamine on L-type calcium current and ATP sensitive potassium current in guinea pig ventricular myocytes |
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| LIANG Yong ,WU Bo Wei ,DUN Wen. Blocking effects of phentolamine on L-type calcium current and ATP sensitive potassium current in guinea pig ventricular myocytes[J]. Acta pharmacologica Sinica, 1998, 0(2) |
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| Authors: | LIANG Yong WU Bo Wei DUN Wen |
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| Affiliation: | LIANG Yong 2,WU Bo Wei 3,DUN Wen |
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| Abstract: | |
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| Keywords: | phentolamine prazosin yohimbine glyburide patch clamp techniques calcium channels potassium channels myocardium |
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