Subacute sclerosing panencephalitis findings at MR imaging, diffusion MR imaging, and proton MR spectroscopy

A case of subacute sclerosing panencephalitis in a 2-year-old boy is reported. In addition to asymmetric lesions in the parietotemporal lobes, right thalamus, and globus pallidus, symmetric patterns were notable in the brain stem, middle cerebellar pedincles, and dentate nuclei. Proton MR spectroscopy revealed markedly decreased N-acetylaspartate peaks and normal choline and myo-inositol levels in the lesions. Diffusion MR imaging revealed an elevated diffusion pattern manifested with high apparent diffusion coefficient values (1.14-1.60 x 10(-3) mm(2)/s) compared with those in normal-appearing brain tissue (0.65-1.00 x 10(-3) mm(2)/s) and subtle high signal intensity characteristics on diffusion-weighted images obtained at b = 1000 s/mm(2).