宫瘤宁胶囊联合复方醋酸棉酚片治疗子宫肌瘤的临床研究

目的探讨宫瘤宁胶囊联合复方醋酸棉酚片治疗子宫肌瘤的临床疗效。方法选取2015年5月—2016年2月在陕西中医药大学第二附属医院进行治疗的子宫肌瘤患者80例,根据治疗方案的差别分为对照组(40例)和治疗组(40例)。对照组口服复方醋酸棉酚片,1片/次,1次/d。治疗组在对照组的基础上口服宫瘤宁胶囊,3粒/次,1次/d。两组患者均连续治疗3个月经周期。比较两组临床疗效、子宫及肌瘤体积变化和促卵泡成熟激素(FSH)、孕酮(P)、雌二醇(E2)、人附睾蛋白4(HE4)和CA125水平变化。结果治疗后,对照组和治疗组总有效率分别为80.00%和95.00%,两组比较差异有统计学意义(P0.05)。治疗后,两组患者子宫体积及肌瘤体积均显著缩小,同组治疗前后差异具有统计学意义(P0.05);且治疗后治疗组的缩小程度优于对照组,两组比较差异具有统计学意义(P0.05)。治疗后,两组E2、P、FSH水平均明显低于同组治疗前(P0.05);且治疗后治疗组这些观察指标显著低于对照组(P0.05)。治疗后,两组患者血清HE4和CA125水平明显降低,同组治疗前后差异具有统计学意义(P0.05);且治疗组上述血清指标降低程度优于对照组,两组比较差异具有统计学意义(P0.05)。结论宫瘤宁胶囊联合复方醋酸棉酚片治疗子宫肌瘤疗效显著,可明显缩小瘤体体积,改善性激素水平及降低机体HE4、CA125水平,具有一定的临床推广应用价值。

Clinical study on Gongliuning Capsules combined with Compound Gosspol Acetate Tablets in treatment of uterine fibroids

Objective To investigate the clinical efficacies of Gongliuning Capsules combined with Compound Gosspol Acetate Tablets in treatment of uterine fibroids. Methods Patients (80 cases) with uterine fibroids in Second Affiliated Hospital of Shaanxi University of TCM from May 2015 to February 2016 were divided into the control (40 cases) and treatment (40 cases) groups according to different treatments. The patients in the control group were po administered with Compound Gosspol Acetate Tablets, 1 tablet/time, once daily. The patients in the treatment group were po administered with Gongliuning Capsules on the basis of the control group, 3 grains/time, once daily. The patients in two groups were treated for three menstrual cycles. After treatment, the clinical efficacies were evaluated, and the changes of uterine and uterine fibroids volume, and FSH, P, E₂, HE4, CA125 levels in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 80.00% and 95.00%, respectively, and there were differences between two groups (P<0.05). After treatment, the volumes of uterine and uterine fibroids in two groups were significantly reduced, and the difference was statistically significant in the same group (P<0.05). And the reduction degree in the treatment group was significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, E₂, P, and FSH levels in two groups were significantly decreased (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, HE4 and CA125 were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the decrease degree of these serum indexes in the treatment group was significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Gongliuning Capsules combined with Compound Gosspol Acetate Tablets has an obvious curative effect in treatment of uterine fibroids, can significantly reduce the tumor volume and improve the sex hormone levels and decrease the levels of CA125 and HE4, which has a certain clinical application value.