丹参川芎嗪注射液联合美托洛尔治疗冠心病心绞痛的疗效观察

目的研究丹参川芎嗪注射液联合美托洛尔治疗冠心病心绞痛的临床疗效。方法选择2013年1月—2015年12月如皋市人民医院收治的冠心病心绞痛患者80例,随机分为对照组和治疗组,每组各40例。对照组患者口服酒石酸美托洛尔片,12.5 mg/次,2次/d。治疗组在对照组的基础上静脉滴注丹参川芎嗪注射液,10 m L加入5%葡萄糖注射液250 m L,1次/d。两组患者均连续治疗2周。观察两组的临床疗效,同时比较两组心绞痛和不良反应发生情况。结果治疗后,对照组和治疗组总有效率分别为85.00%和95.00%,两组总有效率比较差异具有统计学意义(P0.05)。治疗后,对照组心电图总有效率为82.5%,明显低于治疗组的92.5%,两组比较差异具有统计学意义(P0.05)。治疗后,两组患者心绞痛发作次数和持续时间显著减少,同组比较差异具有统计学意义(P0.05);且治疗组发作次数和持续时间都明显少于对照组(P0.05)。治疗期间对照组不良反应发生率为5.0%,治疗组不良反应发生率为7.5%,两组比较差异没有统计学意义。结论丹参川芎嗪注射液联合美托洛尔治疗冠心病心绞痛可提高临床治疗有效率,并且可以改善患者的临床表现,具有一定的临床推广应用价值。

Clinical observation of Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection combined with metoprolol in treatment of coronary heart disease with angina pectoris

Objective To observe the curative effect of Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection combined with metoprolol in treatment of coronary heart disease with angina pectoris. Methods Patients (80 cases) with coronary heart disease with angina pectoris from January 2013 to December 2015 in the People''s Hospital of Rugao were randomly divided into control and treatment group, and each group had 40 cases. Patients in the control group were po administered with Metoprolol Tartrate Tablets, 12.5 mg/time, twice daily. The patients in the treatment group were iv administered with Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection on the basis of the control group, 10 mL added into 5% Glucose Injection 250 mL, once daily. The patients in two groups were treated for 2 weeks. After treatment, the clinical efficacy was evaluated, and the occurrence of angina pectoris and adverse reactions in two groups were compared. Results After treatment, the efficacies in the control and treatment groups were 85.00% and 95.00%, respectively, and there were differences between two groups (P<0.05). After treatment, the total effective rate of electrocardiogram in the control group (82.5%) was significantly lower than that in the treatment group (92.5%), and there were differences between two groups (P<0.05). After treatment, frequency and duration of angina pectoris of two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the frequency and duration of angina pectoris in the treatment group was significantly less than that in the control group (P<0.05). During treatment, the incidence of adverse reactions in the control and treatment groups were 5.0% and 7.5%, respectively, and there was no difference between two groups. Conclusion Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection combined with metoprolol can improve clinical efficiency and symptoms in treatment of coronary heart disease with angina pectoris, which has a certain clinical application value.