卵磷脂络合碘联合曲安奈德治疗2型糖尿病视网膜病变的疗效观察

目的探讨卵磷脂络合碘联合曲安奈德治疗2型糖尿病视网膜病变的疗效观察。方法选取2010年9月—2015年9月在深圳市福田区人民医院进行诊治的2型糖尿病视网膜病变患者72例,随机分为对照组和治疗组,每组各36例。对照组玻璃体腔注射醋酸曲安奈德注射液,0.1 m L/次,1次/d。治疗组在对照组基础口服卵磷脂络合碘片,3片/次,3次/d。两组患者均治疗4周。观察两组的临床疗效,比较两组的最佳矫正视力、视网膜厚度和生活质量。结果治疗后,对照组和治疗组的愈显率分别为77.8%、94.4%,两组比较差异有统计学意义(P0.05)。治疗后,两组最佳矫正视力均明显提高,而视网膜厚度均明显下降,同组治疗前后比较差异有统计学意义(P0.05);且治疗组这些观察指标的改善程度明显优于对照组,两组比较差异具有统计学意义(P0.05)。治疗后随访6个月,治疗组自理能力、活动能力、社交和心理评分均明显高于对照组,两组总有效率比较差异有统计学意义(P0.05)。结论卵磷脂络合碘联合曲安奈德治疗2型糖尿病视网膜病变具有较好的临床疗效,可明显改善视力,提高患者生活质量,具有一定的临床推广应用价值。

Clinical observation of iodized lecithin combined with triamcinolone acetonide in treatment of type 2 diabetic retinopathy

Objective To investigate the clinical effect of iodized lecithin combined with triamcinolone acetonide in treatment of type 2 diabetic retinopathy. Methods Patients (72 cases) with type 2 diabetic retinopathy in Futian District Shenzhen People''s Hospital from September 2010 to September 2015 were randomly divided into control and treatment groups, and each group had 36 cases. Patients in the control group were vitreous cavity iv administered with Triamcinolone Acetonide Acetate Injection, 0.1 mL/time, once daily. Patients in the treatment group were po administered with Iodized Lecithin Tablets on the basis of the control group, 3 tablets/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and the best corrected visual acuity, retinal thickness, and quality of life in two groups were compared. Results After treatment, the obvious curative rate in the control and treatment groups were 77.8% and 94.4%, respectively, and there was difference between two groups (P<0.05). After treatment, the best corrected visual acuity in two groups were significantly increased, but the retinal thickness in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Following up for 6 months after treatment, the scores of self-care ability, activity ability, social intercourse, and psychology in the treatment group were significantly higher than those in the control group, and there was difference between two groups (P<0.05). Conclusion Iodized lecithin combined with triamcinolone acetonide has clinical curative effect in treatment of type 2 diabetic retinopathy, and can improve vision, increase quality of life, which has a certain clinical application value.