磁共振技术评估膝关节软骨退变研究进展

磁共振成像(magnetic resonance imaging,MRI)扫描序列及参数的合理选择对清晰成像及临床研究结果的客观评价至关重要。全膝关节磁共振成像积分,波士顿利兹骨关节炎评分系统,MRI膝骨关节炎评分系统,膝骨关节炎软骨修复评分系统等全膝关节的半定量评分系统都能够全面评价膝骨关节炎进展时各组织的影像学改变。随着MRI技术的不断发展,关节软骨的形态学及生理成分的改变可以被定量评估。T2图、弥散加权成像、延迟动态增强成像等软骨成分的定量评估技术能定量监测软骨基质成分的变化,可以在关节软骨形态学破坏之前更早地发现软骨病变。这些定量、半定量评价技术有助于膝骨关节炎的早期诊断和早期预防,同时也为精确评价干预措施的疗效提供了可能。

Progress on magnetic resonance imaging for evaluating the articular cartilage of the knee joint

The reasonable selection of magnetic resonance imaging(MRI) scan sequence and parameters is very important for the objective evaluation of the results of clinical study and high quality imaging. The semi quantitative scoring system of total knee joint including Whole Organ Magnetic Resonance Imaging Score,Boston Leeds Osteoarthritis Knee Score,MRI Osteoarthritis Knee Score,Cartilage Repair Osteoarthritis Knee Score and so on. They can fully evaluate the imaging changes of various organs during the development of knee osteoarthritis. With the continuous development of MRI technology,the morphological and physiological changes of articular cartilage can be quantitatively assessed. T2 mapping,Diffusion Weighted Imaging,and delayed Gadolinium-Enhanced MRI of Cartilage can be quantitatively monitoring changes in cartilage matrix components. These quantitative and semi quantitative evaluation techniques are helpful to detect OA in its early stage,guide clinical early intervention,and also provide the possibility for the accurate evaluation of the therapeutic effect.