人工麝香对抗动物心肌缺血的作用

目的研究人工麝香对抗动物心肌缺血的作用。方法实验动物随机分为模型组、阳性对照硝酸甘油组(小鼠为0.083mg·kg-1,大鼠为0.042mg·kg-1)、人工麝香低、中、高剂量组(小鼠为5、10、20mg·kg-1,大鼠为2.5、5.0、10mg·kg-1)5组。进行小鼠耐缺氧实验,记录存活时间;垂体后叶素诱发大鼠实验性心肌缺血实验,记录大鼠心电图变化;阻断大鼠冠状动脉引起急性心肌缺血,记录心电图变化、心肌酶指标、缺血范围及形态学检查。结果人工麝香延长动物耐缺氧时间(P<0.01或P<0.05);能够改善垂体后叶素引起的心电变化(P<0.05);抑制心肌酶活性的升高,减少心肌缺血范围(P<0.05)。结论通过实验研究表明人工麝香具有抗动物心肌缺血的作用。

Effect of artificial musk on myocardial ischemia in animals

Aim To observe the effect of artificial musk on myocardial ischemia in animals.Methods The animals were divided into five groups randomly:model group,nitroglycerin control group(the rats were 0.083 mg·kg-1,the mice were 0.042 mg·kg-1),artificial musk low,middle and high groups (the rats were 5,10,20 mg·kg-1,the mice were 2.5,5.0,10 mg·kg-1). To mean survival time of hypoxia,the experimental myocardial ischemia was induced by injection of pituitrin iv in adult rats;to blockade the coronary artery and the diversity of electrocardiographic sign,myocardial enzymes,the myocardial infarct size and pathology were recorded and examined.Results The survival time in hypoxia (P<0.01 or P<0.05) was prolonged,the experimental myocardial ischemia by injection of pituitrin(P<0.05) was ameliorated,the myocardial enzymes were inhibited and the myocardial infarct size(P<0.05) was diminished by artificial musk.Conclusions Artificial musk has protective effects on myocardial ischemia in animals.