吡罗昔康外用微乳的制备及其透皮吸收的研究

目的制备吡罗昔康微乳并考察其体外经皮渗透特性。方法采用Lauroglycol FCC为油相、Labrasol、Cremo-phor EL为表面活性剂、Transcutol P、乙醇为助表面活性剂,绘制伪三元相图,制备吡罗昔康O/W微乳。采用智能透皮实验仪,大鼠背部皮肤作为透皮模型,HPLC测定药物透皮浓度,研究吡罗昔康微乳的透皮特性。结果本实验中微乳较优处方含：吡罗昔康0.5%,Lauroglycol FCC10%,Labrasol、Cremophor EL、Transcutol P各13.3%及水50%,吡罗昔康渗透速率可达10.04±1.73μg/（cm2.h）。结论吡罗昔康微乳有很强的透皮能力,有望成为吡罗昔康的新型透皮给药制剂。

Study on preparation and percutaneous absorption in vitro of piroxicam microemulsion

Objective To prepare Piroxicam microemulsion and investigate its transdermal characteristics in vitro.Methods The o/w microemulsion was prepared with the system contained of Lauroglycol FCC as oil phase,Labrasol and Cremophor EL as surfactants,Transcutol P and Ethanol as cosurfactants according to the pseudo-ternary phase diagrams.The transdermal characteristics were evaluated by modified Franz diffusion cell method.Rat＇s skin was used as permeation barrier and the drug concentration was measured by HPLC.Results The optimum formulation consisted of 0.5%Piroxicam,10%Lauroglycol FCC,50%water,13.3%Labrasol,Cremophor El and Transcutol P.The permeation rate of Piroxicam was 10.04±1.73 μg/（cm2·h）.Conclusion The results indicated that the optimum microemulsion system with high permeation rate may be a potential vehicle for the transdermal delivery of Piroxicam.