血清Hcy和hs-CRP水平检测在AMI早期临床诊断中的临床应用

目的 探讨血清同型半胱氨酸(Hcy)、超敏C反应蛋白(hs-CRP)检测在急性心肌梗死(AMI)患者早期诊断中的临床应用价值。方法 采用散射比浊法检测hs-CRP,酶循环法检测Hcy,分别对80例AMI患者,70例心绞痛(AP)患者,50例健康对照者血清Hcy和hs-CRP检测及其分析。结果 AMI组、AP组和对照组的hs-CRP(mg/L)水平依次为8.06±1.66,4.55±0.90和2.54±0.35,疾病组与对照组比较差异均有统计学意义(F=4.156,P=0.036 9); AMI组较AP组明显增高,差异有统计学意义(P<0.05 )。AMI组、AP组和对照组的Hcy(μmol/L)分别为36.37±7.54,22.67±3.94和11.28±1.73,疾病组与对照组比较差异均有统计学意义(F=3.264,P=0.023 4),AMI组较AP组明显增高,差异有统计学意义(P<0.05 )。AMI组和AP组的hs-CRP水平与Hcy水平均呈正相关(P<0.05)。结论 AMI患者血清Hcy,hs-CRP水平明显增高,二者联合检测对AMI的发生发展有重要价值。

Application Value of Serum Hcy and hs-CRP Levels in Early Diagnosis of AMI

Objective To investigate the clinical application value of serum homocysteine(Hcy)and high sensitive C reactive protein(hs-CRP)in early diagnosis of patients with acute myocardial infarction(AMI).Methods Hs-CRP were determined by scattering turbidimetry,enzymatic cycling assay was used to detect Hcy.Detected and analyzed serum Hcy and hs-CRP level in 80 cases of acute myocardial infarction(AMI)patients,70 cases of angina pectoris(AP)patients and 50 healthy controls.Results The levels of hs-CRP in AMI group,AP group and control groupwere 8.06±1.66 mg/L,4.55±0.90 mg/L and 2.54±0.35 mg/L.The difference between disease group and control group was statistically significant(F=4.156,P=0.036 9).AMI group was significantly higher than of AP group,the difference was statistically significant(P<0.05).The levels of Hcy in AMI group,AP group and control group were 36.37±7.54 μmol/L,22.67±3.94 μmol/L and 11.28±1.73 μmol/L respectively.The difference between disease group and control group were statistically significant(F=3.264,P=0.023 4),AMI group was significantly higher than that of AP group,the difference was statistically significant(P<0.05).The levels of hs-CRP in AMI group and that in AP group and were positively correlated(P<0.05).Conclusion Serum Hcy and hs-CRP levels were significantly elevatedin patients with acute myocardial infarction,combined detection of this two factors would have important value in the occurrence and development of acute myocardial infarction.