血清NGAL与肾功其它指标联合检测在原发性高血压肾病早期诊断中的应用

目的 检测血清中性粒细胞明胶酶相关脂质运载蛋白(NGAL)浓度,探讨其与胱抑素 C(Cys-C)、视黄醇结合蛋白(RBP)、尿素(BUN)和肌酐(Cr)联合测定在原发性高血压早期肾脏损害中的应用价值。方法 选择2014年8月～2016年3月于陕西省人民医院就诊并经确诊的128例原发性高血压患者,将其分为单纯原发性高血压组、原发性高血压并发肾病组和原发性高血压并发肾衰组,同时选择100例健康体检者作为对照组。采用日立7170A全自动生化分析仪对各组血清NGAL与Cys-C,RBP,BUN和Cr水平进行检测,其结果进行统计学分析。结果 各组血清NGAL,Cys-C,RBP,BUN和Cr的检测结果中,单纯原发性高血压组与正常对照组之间差异均无统计学意义(P均>0.05); 原发性高血压并发肾病组与正常对照组、单纯原发性高血压组比较差异均有统计学意义(P均<0.05); 原发性高血压并发肾病组和原发性高血压并发肾衰组血清NGAL与正常对照组、单纯原发性高血压组差异均有统计学意义(P均<0.01); 而原发性高血压并发肾病组NGAL与Cys-C之间差异无统计学意义(P>0.05)。各组NGAL,Cys-C,RBP,BUN和Cr检测异常率方面,原发性高血压并发肾病组均显著高于正常对照组和单纯原发性高血压组,差异有统计学意义(P均<0.01),但BUN,Cr远低于原发性高血压并发肾病组NGAL的异常率(P<0.01)。而原发性高血压并发肾衰组的NGAL,Cys-C,RBP,BUN和Cr异常率略有差异,但差异均无统计学意义(P>0.05)。结论血清NGAL的检测在原发性高血压肾病早期诊断中具有重要的意义,如果联合肾功其它指标的检测可为临床诊断和评估原发性高血压早期肾脏损害以及损害的程度提供重要依据。

Application of Detecting Serum NGAL Combined with Other Renal Function Index in Early Diagnosis of Essential Hypertension Nephropathy

Objective To investigate clinical application value of detectiing serum NGAL combined with Cys-C,RBP,BUN and Cr in primary pypertension patients with early renal damage.Methods Selection of 128 patients with essential hypertension who were diagnosed in Shaanxi Provincial People's Hospital from August 2014 to March 2016.Selected 128 cases ofessential hypertension patients diagnosed clinically,which could be divided into simple essential hypertension group,essential hypertension with nephropathygroup and essential hypertension with renal failure group,and while 100 cases of healthy persons was as normal control group.The serum NGAL,Cys-C,RBP,BUNand Cr in each group were determined with Hitachi 7170A Automatic Biochemical Analyzer,and the measured data were processed by statistical analysis.Results In the detection results of serum NGAL,Cys-C,RBP,BUN and Cr,compared each group,there was not statistical difference in the simple essential hypertension group and the normal control group(P>0.05),but there were statistical differences in the essential hypertension with nephropathy group and the normal control group,and the simple essential hypertension group(P< 0.05).Serum NGAL,there were statistical differences in the essential hypertension with nephropathy group,the essential hypertension with renal failure group and simple essential hypertension group,the normal control group,but there was no statistical difference between NGAL and Cys-C essential hypertension with nephropathy group(P>0.05).The positive rates of NGAL,Cys-C,RBP,BUN and Cr in each group,the essential hypertension with nephropathy group was significantly higher than the normal control group and the simple essential hypertension group(P<0.01),but positive rates of BUN,Cr were far less than the positive rate of NGAL in essential hypertension with nephropathy group(P<0.01).The positive rates of the serum NGAL,Cys-C,RBP,BUN and Cr in thethe essential hypertension with renal failure group had slight difference,butno statistical significance(P>0.05).Conclusion Detection of serum NGAL is of great significance for the early diagnosis of essential hypertension with nephropathy.If the detection combined with other renal function indexes,it can provide an important basis for clinical diagnosis and assessment of essential hypertension with early kidney damage and damage degree.