血清25-(OH)D水平在胃癌患者中的临床意义

目的 研究血清25-羟基维生素D25-(OH)D]水平在胃癌患者中的临床意义,并且探讨血清25-(OH)D与胃癌进展的关系。方法 采用免疫电化学发光法检测胃癌患者和健康对照者的血清25-(OH)D浓度,进行统计学分析,比较胃癌患者和健康对照者的血清25-(OH)D浓度有无统计学差异,比较不同临床分期、组织分化程度、肿瘤大小、远行转移等指标下对应的胃癌患者血清25-(OH)D水平的差异有无统计学意义。结果 胃癌组血清25-(OH)D水平(10.12±5.78ng/ml)显著低于对照组(18.12±7.36 ng/ml)(t=8.51,P<0.001)。胃癌Ⅰ期的血清25-(OH)D水平显著高于胃癌Ⅲ期(P=0.01)和胃癌Ⅳ期(P=0.006)的水平。胃癌高分化组患者的血清25-(OH)D水平显著高于中分化、低分化和未分化组的水平(均P<0.001)。血清25-(OH)D水平与胃癌淋巴结转移、远行转移、肿瘤大小、肿瘤位置均无显著相关性(均P>0.05)。结论 胃癌患者25-(OH)D比健康对照者低; 胃癌的临床分期越晚,维生素D水平越低; 组织学分化程度越低,维生素D水平越低。

Clinical Significance of Serum 25-Hydroxyvitamin D Level of Gastric Cancer Patients

Objective To explore the significance of serum 25-hydroxyvitamin D25-(OH)D] level and the risk of gastric cancer,and investigate the correlation between 25-(OH)D level and the clinic-pathologicalcharacteristics of patients with gastric cancer.Methods The immune-chemiluminescence method was used to measure the serum 25-(OH)D level in order to compare the difference of gastric cancer patients and healthy controls.The general features of patients with gastric cancer(such as age,gender,nationality,sampling season,smoking and drinking status)and clinic-pathological data(such as clinical stage,histological differentiation,lymph node metastasis,tumor size,tumor metastasis,tumor site)were collected.Explored therelationship between various clinic-pathological features and 25-(OH)D level in gastric cancer patients.Analysis of variance and t-test were used to compare the differences of 25-(OH)D level at various indexes such as clinical stage,differentiation degree,tumor size and metastasis.Results 25-(OH)D level was 10.12±5.78 ng/ml and 18.12±7.36 ng/ml in gastriccancer group and control group,respectively.Serum 25-(OH)D level of the gastric cancer group was significantly lower than that in the control group(t=8.51,P<0.001).There was a significant difference of serum 25-(OH)D in different clinical stages of gastric cancer patients(F=3.26,P=0.025).Serum 25-(OH)D level of Gastric cancer stage Ⅰpatients was significantly higher than that of stage Ⅲ(P=0.01)and stage IV(P=0.006).With the improvementof the tumor differentiation,serum 25-(OH)D levels showed an increasing trend.Serum 25-(OH)D level of high differentiated group was significantly higher than that of low differentiation,moderate differentiated and undifferentiated group(P<0.001).No significant relationship were found between serum 25-(OH)D level and lymph node metastasis,tumor metastasis,tumor size,and tumor site(P>0.05).Conclusion Serum 25-(OH)D level represented the vitamin D status of the body.This study elucidated the vitamin D level in patients with gastric cancer was lower than that in healthy controls.Low vitamin D level may be the prediction of high risk of gastric cancer.The later clinical stage,the lower vitamin D level.The poorer the histological differentiation degree,the lower level of vitamin D.