| Prostasin基因在前列腺细胞株中表达情况研究 |
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| 引用本文： | 陈策,孙颖浩,许传亮.Prostasin基因在前列腺细胞株中表达情况研究[J].中国男科学杂志,2005,19(4):5-7. |
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| 作者姓名： | 陈策 孙颖浩 许传亮 |
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| 作者单位： | 第二军医大学附属长海医院泌尿外科,上海,200433 |
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| 摘 要： | 目的 探讨Prostasin在前列腺癌中的功能。方法 运用RT-PCR方法检测人前列腺增生细胞株BPH-1，无转移能力前列腺癌细胞株LNCaP，及有转移能力的前列腺癌细胞株PC-3、DU-145中Prostasin基闪表达情况。结果 Prostasin基斟在BPH-l和LNCaP中正常表达，在PC-3、DU-145中低表达。BPH-l中Prostasin的表达与DU-145和PC-3比较差异有显著性，同样LNCaP中Prostasin的表达与DU-145和PC-3比较差异亦有显著性（P〈0．01）。BPH-1与LNCaP之间表达差异无显著性，DU-145和PC-3之间表达差异亦无显著性，（P〉0.05）。结论 ProStasin可能是前列腺癌的转移抑制剂。
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| 关 键 词： | 前列腺癌 Prostasin基因 转移 基因表达 |
| 修稿时间： | 2004年11月15 |
The expression of Prostasin gene in prostate cell lines |
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| CHEN Ce,SUN Yinghao,XU Chuanliang.The expression of Prostasin gene in prostate cell lines[J].Chinese Journal of Andrology,2005,19(4):5-7. |
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| Authors: | CHEN Ce SUN Yinghao XU Chuanliang |
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| Institution: | Chen Ce,Sun Yinghao,Xu ChuanliangDeparment of Urology,Changhai Hospital Affiliated to Second Military Medical University,Shanghai 200433,China |
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| Abstract: | Objective To explore the function of prostasin in prostate cancer. Methods RT-PCR analyseswere used to examine the expression of prostasin in prostate cancer cell lines. Results Prostasin mRNA was found tobe normal expressed in benign prostate hyperplasia cells line (BPH-1) and a non-invasive human prostate cancercell lin(eLNCaP), but it was found to be lowly expressed in invasive human prostate cancer cell lines DU-145 andPC-3. The expressions of Prostasin mRNA in BPH-1 and LNCaP are higher than those in DU-145 and PC-3. (P<0.01).The difference of the expressions of Prostasin mRNA between BPH-1 and LNCaP are not statistically significant (P>0.05).Also the difference between DU-145 and PC-3 are not statistically significant (P>0.05). Conclusion Our data indicatethat prostasin may be the suppressor of prostate cancer invasion. |
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| Keywords: | prostate cancer prostasingene invasion gene expression |
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