| 急性冠脉综合征患者氯吡格雷抵抗的研究进展 |
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| 引用本文： | 吕海辰,吴鸿谊,葛均波.急性冠脉综合征患者氯吡格雷抵抗的研究进展[J].大连医科大学学报,2014,36(4):387-392. |
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| 作者姓名： | 吕海辰 吴鸿谊 葛均波 |
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| 作者单位： | 复旦大学 附属中山医院 心内科，上海市心血管病研究所，上海 200032 |
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| 摘 要： | 氯吡格雷是一种临床常见的抗血小板药物，在急性冠脉综合征患者中应用广泛。长期随访发现，部分患者对氯吡格雷无反应或低反应，即存在药物抵抗现象。氯吡格雷低抗者的血小板聚集率高、不良心血管事件发生率增加。本文对氯吡格雷的作用机制、氯吡格雷抵抗的检测方法、原因及治疗对策等作一综述。
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| 关 键 词： | 急性冠脉综合征 血小板 氯吡格雷 抵抗 acute coronary syndrome ( ACS) |
| 收稿时间： | 3/9/2014 12:00:00 AM |
| 修稿时间： | 2014/6/27 0:00:00 |
Progress of research on clopidogrel resistance in the patients with acute coronary syndrome |
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| LV Hai-chen,WU Hong-yi,GE Jun-bo.Progress of research on clopidogrel resistance in the patients with acute coronary syndrome[J].Journal of Dalian Medical University,2014,36(4):387-392. |
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| Authors: | LV Hai-chen WU Hong-yi GE Jun-bo |
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| Institution: | (Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, China) |
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| Abstract: | Clopidogrel plays a significant role in the prevention of thrombotic events in patients with acute coronary syn -drome,but a substantial number of patients demonstrate no response or low response to the drug ,which is regarded as the phenomenon of drug resistance .Clopidpgrel-resistance patients have higher platelet aggregation and more frequency to suf -fer from adverse cardiovascular events than the others .The mechanism of the reaction and resistance of clopidogrel , meas-urement of clopidogrel resistance together with the treatment strategy are compeahended in this article . |
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| Keywords: | platelet clopidogrel resistance |
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