Calmodulin content in chondrosarcomas

The content of calmodulin in chondrosarcomas was notably lower in patients with early relapses or generalized tumor process in comparison with patients without postoperation relapses. The mean level of calmodulin in chondrosarcomas virtually did not depend on patient's sex and age and tumor location in bones. There was a tendency to an inverse correlation between calmodulin level in chondrosarcoma and the degree of tumor differentiation. The highest level of calmodulin was detected in the cytosolic fraction of chondrosarcomas containing no estrogen and androgen receptors. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 129, No. 2, pp. 198–200, February, 2000