地参祛风合剂治疗变应性鼻炎的随机对照临床研究

目的：观察地参祛风合剂治疗变应性鼻炎（allergic rhinitis，AR）的临床疗效。 方法：选择变应性鼻炎患者60例，随机分为治疗组30例，对照组30例。分别口服地参祛风合剂及西替利嗪片。观察治疗前后患者的症状（喷嚏、流涕、鼻堵、鼻痒）积分，鼻甲部体征积分，外周血嗜酸性粒细胞计数。 结果：地参祛风合剂可以明显改善变应性鼻炎的各种症状及体征；地参祛风合剂治疗总有效率为83．3％，西替利嗪治疗总有效率为86．7％，两组外周血嗜酸性粒细胞计数明显减少，差异无统计学意义。 结论：地参祛风合剂是治疗变应性鼻炎的有效中药制剂。

Dishen Qufeng Decoction for treating allergic rhinitis: a randomized controlled trial

OBJECTIVE: To observe the clinical therapeutic effects of Dishen Qufeng Decoction (DSQFD), a compound traditional Chinese herbal medicine, in treatment of allergic rhinitis. METHODS: Sixty cases of allergic rhinitis were selected and randomized into DSQFD group (30 cases) and cetirizine group (30 cases), and the patients were orally administered DSQFD and cetirizine respectively. The integrals of patients' symptoms, such as sneezing, nose running, nasal occlusion and nasal itching, signs in the nasal conchae and peripheral blood eosinophil (EOS) count were abserved count before and after treatment. RESULTS: DSQFD obviously improved the symptoms and signs of allergic rhinitis. The total response rate of DSQFD treatment was 83.3%, while that of the cetirizine treatment was 86.7%; the EOS counts in both groups were significantly decreased. These results showed statistical difference between the two groups. CONCLUSION: DSQFD is an effective preparation of traditional Chinese medicine for treating allergic rhinitis.