碱性成纤维细胞生长因子治疗角膜异物疗效分析

目的 分析碱性成纤维生长因子在角膜异物损伤中的治疗效果.方法 收集556例角膜异物伤的患者,按随机数字表法分为两组,A组288例,行角膜异物剔除术后用氧氟沙星滴眼液＋0.9%氯化钠注射液（做为空白对照）滴眼;B组268例,行角膜异物剔除术后用氧氟沙星滴眼液＋碱性成纤维细胞生长因子滴眼液滴眼.比较两组的疗效并分析角膜损伤深度与效果的关系.结果 治疗1周后,A组治愈212例,显效44例,有效23例,无效9例,治愈率为73.61%（212/288）;B组治愈232例,显效26例,有效8例,无效2例,治愈率为86.67%（232/268）,两组疗效（Z=-4.387,P＜0.05）及治愈率（χ2=14.214,P＜0.05）差异均有统计学意义.两组中Ⅰ级损伤患者治愈率均为100.00%;A组Ⅱ级损伤患者治愈率56.21%（86/153）,低于B组的78.76%（115/146）（χ^2=17.525,P＜0.05）;A组Ⅲ级损伤患者治愈率为40.00%（6/15）,低于B组的64.29%（9/14）（χ^2=4.326,P＜0.05）;A、B两组内Ⅱ级损伤治愈率均高于Ⅲ级（χ^2=4.761、5.824,均P＜0.05）.结论 角膜异物剔除术后使用碱性成纤维细胞生长因子滴眼液滴眼更有利于角膜创面的恢复;异物越深,疗效相对较差.

Effect of topical basic fibroblast growth factor in the treatment of corneal foreign bodies

Objective To investigate the effect of topical basic fibroblast growth factor in treating corneal foreign bodies. Methods 556 patients with corneal foreign bodies were collected and were randomly divided into A group （288 cases） and B group（268 cases）. Patients in A group accepted corneal foreign bodies removal surgery, then were given ofloxacin eye drops and normal saline drops, while patients in B group were given ofloxacin eye drops and topical basic fibroblast growth factor eye drops after corneal foreign bodies removal surgery. And the relationship between treatment methods and prognosis was investigated. Results After treatment for 1 week,in A group,there were 212 cases healed,44 cases were excellent improved,23 cases were valid and 9 case were invalid, the cure rate was 73.61% （212/288） ;in B group,there were 232 cases healed,26 cases were excellent improved, 8 cases were valid, 2 cases were invalid, the cure rate was 86.67 % （232/268）, and the differences between the two groups were statisti- cally significant（ X^2 = 14.214 ,P 〈 0.05 ）. The cure rate of degree I in the two group was 100.00%. The cure rate of degree II in A group was 56.21% （86/153）, which was significantly lower than 78.76% （115/146） in B group （X^2 = 17. 525 ,P 〈0.05 ）. The cure rate of degree HI in A group was 40.00% （6/15）,which was significantly lower than 64.29% （9/14） in B group （ X2 = 4. 326, P 〈 0. 05 ）. Conclusion Corneal foreign bodies removal surgery combined with topical basic fibroblast growth factor eye drops can accelerate the recovery of corneal wound.