脐带血干细胞移植治疗失代偿期肝硬化临床分析

目的：观察脐带血干细胞移植方法在治疗失代偿期肝硬化方面的临床疗效。方法采集健康分娩产妇脐带血分离脐带血干细胞，经股动脉入肝固有动脉注射治疗20例肝硬化失代偿患者，移植1周、2周、4周和8周后分别观察血常规、肝功能和凝血功能等指标变化以及临床症状变化情况及不良反应发生情况。结果移植后1周，80％以上患者乏力、食欲不振情况有所缓解，各指标虽有所改变但是不显著（ t＝0.88、0.80、0．20、0．23、0．56，均P＞0．05）；2周后60％患者腹胀有所缓解，血清白蛋白（ ALB）显著上升（ t＝2.03，P＜0．05）；4周后70％患者腹胀缓解，50％患者腹水消退，血清白蛋白（ALB）、ALT、PT均有显著改善（t＝3．84，P＜0．01；t＝1．75、3．02，均P＜0．05）；8周后75％患者腹水消退，除AST不明显外，其他指标均有显著改善（ t＝2．20、2．22、5．93，均P＜0．05）。除1例出现低热外其他患者无不良反应发生。结论脐血干细胞移植方法治疗失代偿期肝硬化可达到一定的短期治疗效果，特别是在增加ALB水平和减少PT方面效果较为显著，可以对肝脏损伤起到一定的恢复作用，同时也具有相对较高的安全性。

Clinical analysis of umbilical cord blood stem cell transplantation in the treatment of decompensated hepatic cirrhosis

Objective To observe the clinical effect of umbilical cord blood stem cell transplantation in the treatment of decompensated hepatic cirrhosis .Methods The umbilical cord blood of healthy puerperal women was collected,and stem cells were isolated and injected into liver through hepatic artery to treat 20 patients withdecompensated＆nbsp;cirrhosis.Blood,liver function,coagulation changes ,indicators of clinical symptoms and adverse events were observed after transplantation 1 week,2 weeks,4 weeks and 8 weeks.Results 1 week after transplantation ,the fatigue,loss of appetite situation were improved in more than 80% patients,but the changes were not significant （ t=0.88,0.80, 0.20,0.23,0.56,all P〉0.05）.2 weeks after transplantation,the bloating of 60% patients was improved,ALB in-creased significantly（t=2.03,P〈0.05）.After 4 weeks,the bloating of 70%patients relieved,50%of patients with ascites subsided.ALB,ALT,PT were significantly improved （t=3.84,P 〈0.01;t =1.75,3.02,all P〈0.05）;8 weeks later,75%of patients with ascites subsided .Except for AST was not obvious ,other indicators were improved significantly（t=2.20,2.22,5.93,all P〈0.05）.Except for one case had low fever ,there were no other adverse reac-tions.Conclusion Cord blood stem cell transplantation in the treatment of decompensated cirrhosis can achieve a certain short-term treatment effects , especially in increasing the level of ALB and reducing PT , could resume liver damage and has relatively high security at the same time .