小儿肺炎患者血清降钙素原和C反应蛋白水平变化及其临床意义

目的 探讨血清降钙素原（PCT）和CRP水平与小儿肺炎的关系及临床意义.方法 分别采用电化学发光法和免疫比浊法检测418例小儿肺炎患者与120例健康儿童血清PCT和CRP含量.结果 肺炎组血清PCT和CRP水平明显高于健康对照组（F=24.13、8.73,均P＜0.05）；细菌性肺炎组血清PCT和CRP水平高于病毒性肺炎组（t=23.58、38.77,均P＜0.05）,支原体性肺炎组CRP水平高于病毒性肺炎组（t=38.37,P＜0.05）,病毒性与支原体肺炎组PCT水平差异无统计学意义（t=3.80,P＞0.05）,且血清PCT和CRP水平随着肺炎的严重程度的加重而增高.结论 血清PCT和CRP测定可作为小儿肺炎早期诊断和鉴别诊断的常规指标,且病情越重升高越明显,其水平变化有助于肺炎严重程度的评估.

Alteration of PCT and CRP in children with pneumonia and its clinical significance

Objective To explore the relationship between serum levels of procalcition （PCT）,CRP and pneumonia,and its clinical significance.Methods Serum levels of PCT and CRP were measured with electrochemiluminescence and immunoturbidimetry respectively in 418 children with pneumonia and 120 healthy children.Results Serum levels of PCT and CRP in pediatric pneumonia group were significantly higher than those of control group（F =24.13,8.73,all P 〈 0.05）.The levels of PCT and CRP in the bacterial pneumonia group were higher than those of viral pneumonia group （t =23.58,38.77,all P 〈 0.05）.The CRP level of mycoplasmal pneumonia group,was higher than that of the viral pneumonia group （t =38.37,P 〈 0.05）,while the serum PCT level between the viral pneumonia group and mycoplasmal pneumonia group had no significant difference （t =3.80,P 〉 0.05）.The serum PCT and CRP levels were gradually increased with the aggravation of the pneumonia.Conclusion Determination of serum PCT and CRP can be used as a conventional index for early diagnosis and differential diagnosis of pediatric pneumonia.In addition,the serum levels of PCT and CRP gradually increased with the increase of the severity,its level can help to assess the severity of pneumonia.