Severe acute pancreatitis and abnormalities in blood coagulation and fibrinolysis system

In acute pancreatitis, coagulo-fibrinolytic abnormalities may easily result in disseminated intravascular coagulation (DIC). The prognosis will become very poor, once bleeding necrosis or circulatory failure also occur in important internal organs other than the pancreas, leading to multiple organ failure. Changes in blood coagulation and fibrinolysis system may be greatly involved in the severity of acute pancreatitis. In medical treatment, it is necessary to be cautious of predictors of severity, and to perform the early diagnosis of DIC along with quick and positive intensive management.