川芎、黄芪对自发性高血压大鼠胸主动脉外膜成纤维细胞增殖的影响 |
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引用本文: | 钱岳晟,李燕,高平进,顾天华,张照英,吴永杰. 川芎、黄芪对自发性高血压大鼠胸主动脉外膜成纤维细胞增殖的影响[J]. 中国中西医结合杂志, 2003, 0(Z1) |
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作者姓名: | 钱岳晟 李燕 高平进 顾天华 张照英 吴永杰 |
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作者单位: | [1]上海第二医科大学附属瑞金医院上海市高血压研究所 [2](上海 [3]200025) |
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基金项目: | 上海市教育委员会科学发展基金资助(No.99B13) |
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摘 要: | 目的:探讨川芎、黄芪对自发性高血压大鼠(SHR)胸主动脉外膜成纤维细胞增殖的抑制作用。方法:以单用川芎或川芎黄芪合剂的 SHR 血清检测对培养的 SHR 胸主动脉外膜成纤维细胞~3H-胸腺嘧啶核苷(~3H-TdR)掺入的影响。结果:川芎和川芎、黄芪合用对 SHR 的血压和心率没有影响,川芎血清组和川芎黄芪合剂血清组与 SHR 血清组比较,~3H-TdR 的掺入量差异有显著性(P<0.05,P<0.01)。结论:川芎、黄芪能抑制 SHR 胸主动脉外膜成纤维细胞增殖,这些效应可能与它们的钙离子拮抗有关。
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关 键 词: | 川芎 黄芪 血管外膜成纤维细胞 增殖 |
Effect of Ligustcum chuanxiong and Radix Astragalus on the Proliferation of Aortic Adventitial Fibroblasts in Spontaneously Hypertensive Rats |
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Affiliation: | QIAN Yue-sheng LI Yan GAO Ping-jin Ruijin Hospital; Shanghai Second Medical University; Shanghai(200025); |
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Abstract: | Objective:To explore the inhibition of Ligustcum chuanxiong and Radix Astragalus on the proliferation of aortic adventitial fi- broblasts in spontaneously hypertensive rats (SHR).Methods:SHR serum with Ligustcum chuanxiong alone (group A)or with mix- ture of Ligustcum chuanxiong and Radix Astragalus (group B) were used to determine the effect of~3H-thymidine(~3H-TdR)incorpo- ration.Results:No influence of Ligustcum chuanxiong and mixture of Ligustcum chuanxiong & Radix Astragalus on the blood pres- sure and... |
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Keywords: | Ligustum chuanxiong Radix Astragalus vascular adventitial fibroblasts proliferation |
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