Effect of aqueous extract of Ajuga iva supplementation on plasma lipid profile and tissue antioxidant status in rats fed a high-cholesterol diet |
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Authors: | Chenni A Yahia D Ait Boukortt F O Prost J Lacaille-Dubois M A Bouchenak M |
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Affiliation: | Laboratoire de Nutrition Clinique et Métabolique, Faculté des Sciences, Université d'Oran Es Sénia, 31000 Oran, Algeria. |
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Abstract: | The present study was designed to explore the possible antioxidant and hypolipidemic effects of the aqueous extract of Ajuga iva (0.5% in the diet) in rats fed a high-cholesterol (1%) diet (HCD). The results indicated that the HCD-Ai versus HCD treatment led to many changes in biochemical parameters. They showed a decrease of plasma total cholesterol (TC) and VLDL-cholesterol but an increase of HDL(2)-cholesterol. The triacylglycerol contents were reduced in plasma and in VLDL. The lipid peroxidation determined by TBARS was decreased by 75% in plasma. TBARS in liver, heart and kidneys were highly reduced excepted in the adipose tissue. Ajuga iva treatment enhanced superoxide dismutase activity in liver and kidney. Glutathione reductase activity was lowered in adipose tissue but increased in liver and in kidney. A significant increase was noted in glutathione peroxidase activity in liver, heart and kidney but a low value in adipose tissue was observed. In conclusion, the present study demonstrates that in addition to its potent TG and TC-lowering effects, Ajuga iva is effective in improving the antioxidant status by reducing lipid peroxidation in plasma and tissues and enhancing the antioxidant enzymes in rats fed high-cholesterol diet. Furthermore, Ajuga iva may reduce intestinal cholesterol absorption. |
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Keywords: | Ai, Ajuga iva EDTA, ethylene diamine tetracetic acid GSH-GSSG, reduced glutathione-oxidized glutathione GSH-Px, glutathione peroxidase GSH-red, glutathione reductase HCD, high cholesterol diet HDL, high density lipotrotein LCAT, lecithin cholesterol acyltransferase MDA, malondialdehyde PL, phospholipid SDS, sodium dodecylsulfate S.E.M., standard error of mean SOD, superoxide dismutase TBARS, thiobarbituric acid reactive substances TC, total cholesterol TG, triacylglycerol TLC, thin layer chromatography VLDL, very low density lipoprotein |
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