| Increased apoptosis in third-trimester placental tissue from gestations complicated by PIH |
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| 作者姓名： | 王林 辛晓燕 王哲 冯骥良 |
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| 作者单位： | Department of Obstetrics & Gynaecology，Xijing Hospital，Fourth Military Medical University，Department of Obstetrics & Gynaecology，Xijing Hospital，Fourth Military Medical University，Department of Pathology，Fourth Military Medical University，Department of Pathology，Fourth Military Medical University Xi'an 710033，China，Xi'an 710033，China，Xi'an 710033，China，Xi'an 710033，China |
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| 摘 要： | Objective: To investigate a possible role of apoptosis in the pathophysiologic mechanisms of PIH ( pregnancy-induced hypertension syndrome). Methods: In this study, placental samples were obtained from 16 uncomplicated third-trimester pregnancies and from 16 cases of PIH. We used light microscopy, electron microscopy to identify apoptosis. Light microscopy was used to quantify their incidence of apoptosis. Electron microscopy was used to confirm the occurrence of apoptosis. Results: Apoptosis has been conclusively demonstrated within human third-trimester placental tissue. Medians and interquartile ranges of normal placenta (n = 16) was 0. 12% (0. 08% -0. 19% ) ; Medians and interquartile ranges of PIH group (n = 16) was 0. 37% (0. 15% -0.49% ). Compared to normal placentas, the incidence of apoptosis was higher in placentas from gestations complicated by PIH ( P < 0. 05 , T'-test). Conclusion: Placental apoptosis increases significantly in PIH, and it may play a role in the pathophysiologic mechanisms
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| 关 键 词： | 妊娠并发症 PIH 妊高症 胎盘组织 细胞凋亡 妊娠末三月 |
Increased apoptosis in third-trimester placental tissue from gestations complicated by PIH |
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| WANG Lin,XIN Xiao-yan,WANG Zhe FENG Ji-liang.Increased apoptosis in third-trimester placental tissue from gestations complicated by PIH[J].Journal of Medical Colleges of PLA(China),2003,18(1):19-22. |
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| Authors: | WANG Lin XIN Xiao-yan WANG Zhe FENG Ji-liang |
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| Institution: | WANG Lin,XIN Xiao-yan,WANG Zhe FENG Ji-liang
Department of Obstetrics & Gynaecology,Xijing Hospital,Fourth Military Medical University,Xi'an 710033,China Department of Pathology,Fourth Military Medical University,Xi'an 710033,China |
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| Abstract: | Objective: To investigate a possible role of apoptosis in the pathophysiologic mechanisms of PIH ( pregnancy-induced hypertension syndrome). Methods: In this study, placental samples were obtained from 16 uncomplicated third-trimester pregnancies and from 16 cases of PIH. We used light microscopy, electron microscopy to identify apoptosis. Light microscopy was used to quantify their incidence of apoptosis. Electron microscopy was used to confirm the occurrence of apoptosis. Results: Apoptosis has been conclusively demonstrated within human third-trimester placental tissue. Medians and interquartile ranges of normal placenta (n = 16) was 0. 12% (0. 08% -0. 19% ) ; Medians and interquartile ranges of PIH group (n = 16) was 0. 37% (0. 15% -0.49% ). Compared to normal placentas, the incidence of apoptosis was higher in placentas from gestations complicated by PIH ( P < 0. 05 , T'-test). Conclusion: Placental apoptosis increases significantly in PIH, and it may play a role in the pathophysiologic mechanisms of this syndrome . |
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| Keywords: | apoptosis placenta pregnancy-induced hypertension syndrome |
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