The use of a single non-timed urine collection in the calculation of fractional lithium clearance |
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Authors: | M. O’Hagan S. Greene |
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Affiliation: | (1) Department of Child Health, Ninewells Hospital and Medical School, DD1 9SY Dundee, Scotland, UK |
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Abstract: | Summary The fractional clearance of lithium (CLLi/CLcr) calculated in 15 normal healthy adults from a single morning urine aliquot collection, together with a single venous blood sample (FQ) was compared with the average CLLI/CLCR obtained from three timed consecutive urine collections with mid-point blood sampling (FABC). Lithium had been ingested 15–18 h prior to the collection of these samples. Mean CLLi/CLCR was similar (FQ, 0.186, FABC, 0.177), with a highly significant correlation in each individual of CLLI/CLSR measured by either method (r = 0.97,P 0.0001). Proximal tubular reabsorption of sodium using lithium clearance may be calculated from a single urine and blood sample. |
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Keywords: | Lithium clearance Proximal tubule Sodium Fractional clearance |
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