Dilatations géantes des espaces de Virchow-Robin symptomatiques |
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Authors: | S. Gronier X. Ayrignac C. Lamy J. Honnorat P. Thomas C. Lebrun-Frenay P. Labauge |
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Affiliation: | 1. Service de neurologie, pôle de neurosciences cliniques, CHU de Nice, hôpital Pasteur, 30, voie Romaine, 06002 Nice cedex 1, France;2. Service de neurologie, CHU de Montpellier, hôpital Gui-de-Chauliac, 80, avenue Augustin-Fliche, 34295 Montpellier cedex 5, France;3. Service de neurologie, CHU d’Amiens, hôpital Nord, place Victor-Pauchet, 80054 Amiens cedex 1, France;4. Service de neuro-oncologie, CHU de Lyon, hôpital Pierre-Wertheimer, 59, boulevard Pinel, 69500 Bron, France |
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Abstract: | IntroductionPerivascular spaces, known as Virchow-Robin spaces (VRS), may become massively enlarged but are usually an incidental finding. However, a few reports on patients with unusually large VRS have mentioned association with neurological symptoms. We report a series of three symptomatic patients with extremely wide Virchow-Robin spaces documented on brain magnetic resonance imaging (MRI).MethodsWe retrospectively analyzed the medical records and brain MRI of three symptomatic patients, who had been diagnosed with VRS widening.Case reportsIn all three patients, the unusual widening of the VRS was located within the subcortical white matter with asymmetric distribution. Their neurological symptoms were epilepsy and neurological deficits which correlated well with the lesions seen on the MRI. Two patients had associated white matter hyperintensities: in the first case associated gliosis and in the second case, with vascular leukoencephalopathy.ConclusionsEnlarged symptomatic VRS are rare. The underlying pathophysiological mechanisms remain uncertain. We report three cases with symptomatic giant dilatation of the Virchow-Robin spaces. |
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Keywords: | Espaces pé rivasculaires de Virchow-Robin Dilatation des espaces de Virchow-Robin Imagerie par ré sonance magné tique |
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