The role of cell adhesion molecules in ischemic epididymal injury |
| |
Authors: | Hayrettin Öztürk Hulya Ozturk Ali Ihsan Dokucu |
| |
Institution: | (1) Department of Pediatric Surgery, Dicle University, Medical School, 21280 Diyarbakir, Turkey;(2) Department of Pediatric Surgery, Diyarbakir Children Hospital, Diyarbakir, Turkey |
| |
Abstract: | Objective The aim of this study was to investigate the role of adhesion molecules in epididymal injury induced by I–R in the rats.
Study design A total of 20 male Sprague–Dawley rats were separated into two groups. A sham operation was performed in group 1 (control).
In group 2 (I–R), following 6 h of unilateral spermatic cord torsion, 1-h detorsion of the testis was performed. Then, epididymides
were removed to measure the tissue levels of malondialdehyde (MDA) and to make histological examination.
Results MDA values increased in the group 2. In the group 2 rats demonstrated significant disorganization of the epithelium and loss
of microvilli in the epididymal tissue. No abnormal microscopic findings of the epididymis of the rats in the control group.
The tenascin expression in the interstitial area of the epididymis was intense in the group 2. ICAM-1 expression by intense
brown staining was seen along the basement membrane in epididymal tissue from I to R group rats. The microvillus sites of
the epithelia in I–R group were stained mildly by lectin.
Conclusion The increased expression of adhesion molecules found in epididymal injury induced during postischemic reperfusion might implicate
importance of inflammatory infiltration. |
| |
Keywords: | Testicular and spermatic cord torsion Adhesion molecules Rat |
本文献已被 PubMed SpringerLink 等数据库收录! |
|