人工冬虫夏草菌丝体对糖尿病大鼠睾丸的保护作用

目的观察人工冬虫夏草菌丝体对糖尿病大鼠睾丸的保护作用。方法21只Wistar鼠随机分为正常对照组、糖尿病组和治疗组。采用四氧嘧啶腹腔注射复制糖尿病动物模型。金水宝胶囊治疗8周后，测血清葡萄糖、胰岛素、睾酮，以及睾丸高能磷酸化合物、线粒体丙二醛(MDA)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、ATP酶。结果糖尿病组与对照组比较，睾丸线粒体膜发生脂质过氧化，出现能量代谢障碍，ATP酶活性下降。使用金水宝治疗后，睾丸各项测定指标明显改善。结论人工冬虫夏草菌丝体对糖尿病大鼠睾丸有保护作用。

Protective effects of mycelium of cultured Cordyceps sinensis on testis in diabetic rats

Objective To observe the protective effects of mycelium of cultured Cordyceps sinensis on testis in diabetic Wistar rats. Methods 21 rats were divided into control group(C), diabetes group(D) and treatment group (T) at random. Diabetic model was reproduced by intraperitoneal injection of alloxan. After having been treated with Jinshuibao capsule for 8 weeks, serum levels of glucose, insulin, testosterone and levels of high energy phosphate compound, MDA, SOD, GSH-Px, and ATPases in the testis were determined respectively. Results Compared with control group, testicular mitochondria showed lipid peroxidase injury, with disturbed energy metabolism, and the activity of ATPases was lowered. All the changes in serum and testes were improved when Jinshuibao capsule was given. Conclusion Mycelium of cultured Cordyceps sinensis might have protective effects on the testis in diabetic Wistar rats.