| 造血因子对急性髓性白血病细胞动力学的影响 |
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| 引用本文： | 叶奇鲁,于载泺,马瑞英.造血因子对急性髓性白血病细胞动力学的影响[J].北京大学学报(医学版),1995(6). |
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| 作者姓名： | 叶奇鲁 于载泺 马瑞英 |
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| 作者单位： | 北京医科大学第一医院儿科 |
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| 摘 要： | 观察了ｒｈＧＭ－ＣＳＦ，ｒｈＩＬ－３，ｒｈＩＬ－６和ｒｈＩＬ－９单独或配伍与正常和急性髓性白血病（ＡＭＬ）骨髓共同培养不同时间对细胞ＤＮＡ及增殖周期的影响。结果显示正常和ＡＭＬ骨髓经４种造血因子（ＨＧＦｓ）作用后均有异倍体的检出。其异倍体的发生与Ｓ期细胞的增高有一定相关性。ＨＧＦｓ单独或配伍作用７天时ＡＭＬ骨髓细胞Ｓ％的增高明显大于正常骨髓细胞。
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| 关 键 词： | 细胞分化／药物作用，造血细胞生长因子／药理学，白血病，髓母细胞性 |
THE EFFECT OF HGFs ON DYNAMICS OF CELL KINETICS OF BONE MARROW CELLS
IN PATIENTS WITH AML |
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| Institution: | Department of Pediatrics,The First Hospital
Ye Qilu,et al |
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| Abstract: | n vitro effects of rhGM-CSF,rhIL-3,rhIL-6 and
rhIL-9 on dynamics of cell kinetics and DNA synthesis of the
bone marrow cells in patients with AML and normal bone marrow cells
were investigated.The results revealed that the aneuploid cells were
noted in both AML and normal bone marrow cells after incubated with
HGFs.When bone marrow cells were incubated with for 7 days the
proportion of cell in S phases in the patients with AML wax
significantly higher than that in normal bone marrow cells. |
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| Keywords: | Headings Cell differentiation/drug eff Hematopoietic cell growthfactors/pharmacol Leukemia myeloblastic |
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