昆明杯冠藤中C-21甾类成分的研究

目的 研究昆明杯冠藤中C-21甾体类化学成分。方法 利用硅胶色谱法，反相ODS以及高效液相色谱法进行分离纯化，通过理化常数及光谱分析鉴定了化合物结构。结果 从昆明杯冠藤中分离得到了4个C-21甾体类化合物，分别为：告达庭（caudatin,Ⅰ），加加明（gagamine,Ⅱ），告达庭-3-O-β-D-夹竹桃吡喃糖基(1→4)-β-D-加拿大麻吡喃糖基(1→4)-β-D-加拿大麻吡喃糖苷（Ⅲ），青羊参苷元-3-O-β-D-夹竹桃吡喃糖基(1→4)-β-D-加拿大麻吡喃糖基(1→4)-β-D-加拿大麻吡喃糖苷（Ⅳ）。 结论 化合物Ⅲ和Ⅳ中的糖链全部由2，6-双去氧糖组成，且均首次从该植物中分离得到。

C-21 steroidal glycosides from Cynanchum wallichii Wight

Aim To study C-21 glycosides of Cynanchum wallichii Wight. Methods Four compounds were isolated by means of silica gel column ODS column and HPLC, and the structures of these 4 steroidal glycosides were determined on the basis of both their physical and chemical characters and spectral analysis. Results Four steroidal glycosides were isolated from Cynanchum wallichii Wight, and identified as: caudatin(Ⅰ)，gagamine(Ⅱ)，cau-datin-3-O-β-D-oleandropyranosyl-(1→4)-β-D-cymaropyranosyl(1→4)-β-D-cymaropyranoside(Ⅲ), qinyangshengenin-3-O-β-D-oleandropyranosyl-(1→4)-β-D-cymaropyranosyl(1→4)-β-D-cymaropyranoside(Ⅳ). Conclusion sugar chains of compound Ⅲ and Ⅳ were composed of 2,6-dideoxy-pyranoses and both were isolated from Cynanchum wallichii Wight. for the first time.