支气管舒张试验在6至14岁儿童哮喘中的应用

目的探讨支气管舒张试验在儿童哮喘急性发作期和缓解期中的应用价值。方法2006年4月至2006年11月在本院儿科哮喘专科门诊及住院治疗的儿童哮喘病例76例。其中，急性发作期组34例，缓解期组42例，以沙丁胺醇作为支气管舒张剂，用常规肺通气功能分析儿童哮喘发作期与缓解期吸入药物前、后肺功能的变化。结果①吸入支气管舒张剂后，儿童哮喘急性发作期和缓解期的肺功能各项指标明显改善；②两组FEV1，PEF，FEF21改善率比较，差异有显著意义；③两组FEV1，PEF，FEF21的阳性率比较，差异有显著意义；但两组FEV1／FVC，FEF50，FEF75的阳性率比较，差异无显著意义。结论本研究结果显示，儿童哮喘缓解期组患儿的FEV1，PEF，FEF75阳性率低于急性发作期组；儿童哮喘缓解期组患儿的FEV1／FVC，FEF50，FEF75阳性率接近急性发作期。支气管舒张试验在儿童哮喘的诊断和疗效判断中有较好的应用价值。

The Application of Bronchodilation Test in 6 to 14 Years Old Children With Asthma

Objective To evaluate the application of bronchodilation test in exacerbation and remission of asthma in children. Methods Totally 76 children were examined with bronchodilation test in Affilicated Provincial Hospital of Anhui Medical University. They were divided into 2 groups： group of acute exacerbation of asthma （34 cases）, and group of remission of asthma （42 cases）. Both of them were received salbutamol, and the change of 2 groups＇ pulmonary ventilation were evaluated. Results ①After inhaling salbutamol, there were significant recovery in both groups. ②There were significant differences in changes of FEV1, PEF and FEF25 between 2 groups. ③If we used FEV1, PEF and FEF25 as the diagnostic standard, there were significant differences in the positive rate of bronchodilation test between 2 groups. While take FEV1/FVC, FEF50 and FEF75 as the diagnostic standard, there were no differences in the positive rate between 2 groups. Conclusion The positive rate of FEV1, PEF, FEF25 in the remission group is lower than those in the exacerbation group. The positive rate of FEV1/FVC, FEF50, FEF75 has no significant differences between 2 groups. Bronchodilative test has a good value in diagnosis and evaluation therapeutic effect in children with asthma.