Helicobacter pylori cagA Status and s and m Alleles of vacA in Isolates from Individuals with a Variety of H. pylori-Associated Gastric Diseases |
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| Authors: | Dolores G Evans Dulciene M M Queiroz Edilberto N Mendes and Doyle J Evans Jr |
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| Institution: | Department of Medicine, Baylor College of Medicine, and Bacterial Enteropathogens Laboratory, Gastroenterology Section, Veterans Affairs Medical Center, Houston, Texas 77030,1. and Laboratory of Research in Bacteriology, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil2. |
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| Abstract: | The cagA gene was detected in 100% of 16 Helicobacter pylori isolates from patients with gastric carcinoma versus 78% of 18 isolates from patients with duodenal ulcers (P = 0.344) and only 64% of 22 isolates from patients with gastritis only (P = 0.005) in Brazil. Also, there was a significant association between isolation of cagA+ s1-type vacA H. pylori in cases of stomach cancer and ulcers as opposed to cases of gastritis only (P = 0.004), but this was not true in Houston (P = 0.238), where 94% of all isolates were cagA+. |
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