| 长效避孕药——醋炔诺醇环戊丙酸酯的合成 |
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| 引用本文： | 陈炜,邱来康. 长效避孕药——醋炔诺醇环戊丙酸酯的合成[J]. 药学学报, 1984, 19(12): 935-937 |
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| 作者姓名： | 陈炜 邱来康 |
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| 作者单位： | 上海市计划生育科学研究所;**上海市医药局中等专科学校 |
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| 摘 要： | In order to prolong the biological action of norethisterone acetate (Ⅰ) we have synthesized its cyclopentylpropionic ester (Ⅳ). I was reduced to its hydroxy intermediate (Ⅱ) by potassium borohydride in 91% yield and then esterifled with cyclopentyl chloride to give Ⅳ in 49% yield.A single intramuscular dose of 60 mg of cyclopentylpropionic ester of Norethisterone acetate was fo und to protect women from pregnancy for 3 months. The efficacy rate of the contraceptive effect in 1728 cases of clinical trials was about 99.6%.
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| 关 键 词： | 醋炔诺醇 醋炔诺醇环戊丙酸酯 |
| 收稿时间： | 1983-12-30 |
SYNTHESIS OF CYCLOPENTYLPROPIONIC ESTER OF NORETHISTERONE ACETATE AS LONG ACTING CONTRACEPTIVES |
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| CHEN Wei and QIU Lai-Kang. SYNTHESIS OF CYCLOPENTYLPROPIONIC ESTER OF NORETHISTERONE ACETATE AS LONG ACTING CONTRACEPTIVES[J]. Acta pharmaceutica Sinica, 1984, 19(12): 935-937 |
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| Authors: | CHEN Wei and QIU Lai-Kang |
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| Abstract: | In order to prolong the biological action of norethisterone acetate (Ⅰ) we have synthesized its cyclopentylpropionic ester (Ⅳ). I was reduced to its hydroxy intermediate (Ⅱ) by potassium borohydride in 91% yield and then esterifled with cyclopentyl chloride to give Ⅳ in 49% yield.A single intramuscular dose of 60 mg of cyclopentylpropionic ester of Norethisterone acetate was fo und to protect women from pregnancy for 3 months. The efficacy rate of the contraceptive effect in 1728 cases of clinical trials was about 99.6%. |
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| Keywords: | cyclopentylpropionic ester of norethisterol acetate Norethisterol acetate |
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