| 牛磺酸对低水平染铅大鼠生长发育的影响 |
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| 引用本文： | 姜文洁, 张秀珍, 段建华. 牛磺酸对低水平染铅大鼠生长发育的影响[J]. 中国公共卫生, 2002, 18(9): 1069-1070. DOI: 10.11847/zgggws2002-18-09-25 |
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| 作者姓名： | 姜文洁 张秀珍 段建华 |
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| 作者单位： | 1.青岛大学医学院预防医学教研室 青岛266021 |
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| 基金项目： | 卫生部科学基金资助(96-1-356) |
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| 摘 要： | 目的探讨牛磺酸对低水平染铅大鼠生长发育的影响。方法用0.14%醋酸铅蒸馏水建立大鼠低水平染铅模型,从行为毒理学角度观察补充不同浓度牛磺酸是否能保护其子代正常生长发育,并测定幼鼠血铅、脑铅含量。结果(1)各牛磺酸补充组的幼鼠脑铅含量均低于铅对照组,但高于对照组(P<0.01).(2)负向趋地、听觉惊愕、触须定位达标时间(天)各铅加牛磺酸组均短于铅对照组(P<0.01)。结论补充牛磺酸可以减少铅在幼大鼠脑内蓄积,防止铅毒性所致幼大鼠的行为发育迟缓。
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| 关 键 词： | 牛磺酸 铅中毒 发育 行为 大鼠 |
| 文章编号： | 1001-0580(2002)09-1069-02 |
| 收稿时间： | 2001-09-27 |
| 修稿时间： | 2001-09-27 |
Effects of Taurine on Development of Rats Exposed to Low - Level Lead |
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| JIANG Wen-jie, ZHANG Xiu-zhen, DUAN Jian-hua. Effects of Taurine on Development of Rats Exposed to Low-Level Lead[J]. Chinese Journal of Public Health, 2002, 18(9): 1069-1070. DOI: 10.11847/zgggws2002-18-09-25 |
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| Authors: | JIANG Wen-jie ZHANG Xiu-zhen DUAN Jian-hua |
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| Affiliation: | 1.Department of Preventive Medicine, Medical College of Qingdao University, Qingdao 266021, China |
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| Abstract: | ObjectiveTo assess the effects of taurine supplementation on development of youngrats ex posed to low-level lead.MethodsLow level poisoning lead model of rat was set up in order to observe the protection of supplementing different dose of taurine on the normal development of rat's offspring.The adolescent's blood lead,cerebral lead were measured.ResultsYoungrat's cerebral-lead contents of all taurine-supplementation groups were low than lead groups,higher than control group(P<0.01).The time(day)of negative tendency,aural stun,cirrus locat ion of lead+taurine groups is shorter long lead group(P<0.01).ConclusionSupplementing taur ine could reduce lead deposit in youngrat's brain and prevent retardation on behavioral development from lead poison. |
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| Keywords: | taurine lead poisoning development behavior rat |
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