| 乙型肝炎患者血清前S1抗原检测的临床意义 |
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| 引用本文： | 武红梅.乙型肝炎患者血清前S1抗原检测的临床意义[J].西部医学,2008,20(1):178-179. |
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| 作者姓名： | 武红梅 |
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| 作者单位： | 达州市第二人民医院,四川,达州,635000 |
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| 摘 要： | 目的探讨乙型肝炎患者血清乙肝病毒前S1抗原检测的临床意义。方法乙肝患者血清标志物用ELISA法测定，并根据不同的模式分成四组；均用乙肝病毒前S1诊断试剂测定，方法为ELISA；用荧光定量PCR测定上述四组血清标本的HBV—DNA。结果704例乙肝患者血清标本中乙肝病毒前S1抗原阳性491例，阳性率69．7％；乙肝患者血清标本中HBV—DNA阳性511例，阳性率72复制的一个可靠指标。
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| 关 键 词： | 前S1抗原 乙肝病毒 乙肝血清标志物 HBV—DNA PCR |
| 文章编号： | 1672-3511（2008）01-0178-02 |
| 收稿时间： | 2007-06-08 |
| 修稿时间： | 2007-08-20 |
Clinical significance of serum pro-S1 antigen detection in type B hepatitis patients |
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| WU Hong-mei.Clinical significance of serum pro-S1 antigen detection in type B hepatitis patients[J].Medical Journal of West China,2008,20(1):178-179. |
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| Authors: | WU Hong-mei |
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| Institution: | WU Hong-mei (Dazhou Second Hospital, Dazhou 635000 ,Sichuan, China) |
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| Abstract: | Objective To evaluate the clinical significance of HBV pro-S1 antigen detection. Methods We use ELISA method to measure the serum markers from the samples of type B hepatitis patients. The samples were divided into four groups according to different modes. HBV pro-S1 antigen diagnostic reagent was used to determine the 4 groups of serum specimens by ELISA method, and fluorescent quantitation PCR to measure the serum specimen HBV- DNA. Results There were 491 cases who were positive for HBV pro-S1 antigen out of 704 cases of type B hepatitis patients, and the positive rate was 70%. There were 511 cases who were HBV-DNA positive, and the positive rate was 73%. The results from the two methods of measurement were roughly identical. Conclusion Serum HBV pro-S1 antigen is a reliable indicator indicating HBV replication in vivo. |
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| Keywords: | Pro-S1 antigen Hepatitis B virus Type B hepatitis serum marker HBV-DNA PCR |
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