非球面人工晶状体在个体化人眼模型中成像质量的研究

目的 根据不同患者眼部解剖参数建立个体化眼模型,研究植入不同设计的人工晶状体（IOL）后的光学表现.方法 计算机数字模拟实验.采用Pentacam眼前节分析系统、IOL Master采集白内障摘除联合IOL植入术后人眼结构数据,应用ZEMAX光学设计软件建立个体化眼模型,分别模拟植入不同设计的3种非球面IOL（SofPort AO、Tecnis Z9000、FY60AD）和1种球面IOL（YA60BBR）,计算这些IOL眼3 mm、4 mm、5 mm瞳孔下的调制传递函数（MTF）和对比敏感度函数（CSF）曲线.结果 随瞳孔直径增加,全眼MTF、CSF曲线高度下降；3 mm瞳孔下,个体化眼模型中3种非球面IOL的MTF和CSF曲线与球面IOL接近；5 mm瞳孔下,个体化眼模型植入4种IOL后MTF和CSF曲线差异明显,不同解剖结构参数个体获得最佳MTF和CSF曲线的IOL种类不同,在空间频率较高时更加明显.结论 根据人眼解剖参数建立个体化眼模型可以模拟该个体眼睛光学系统的光学质量.不同解剖结构的人眼光学系统获得最佳视觉质量所需的IOL种类不同.

Optical quality of aspheric intraocular lenses in individual eye models

Objective An aspheric intraocular lens (IOL) with fixed spherical aberration (SA) implanted in an individual patient will not always obtain ideal optical quality since human corneal structure and SA have large individual variations.The aim of this research was to study optical performance of individual pseudophakic eye models that were constructed based on individual anatomic parameters and implanted IOL with different optical designs.Methods Computer numerical simulation experiment.The anatomic parameters of individual pseudophakic patients were obtained by Pentacam and IOL Master.Parameters were input into ZEMAX to build individual eye models.Three aspheric IOL (SofPort AO,Tecnis Z9000,FY60AD) and one spherical IOL (YA60BBR) were implanted into individual eye models.Modulation transfer function (MTF) and contrast sensitivity function (CSF) were calculated for 3 mm to 5 mm pupil diameters and 550 nm wavelength.Results The height of the MTF and CSF curves were decreased with larger pupils.They were similar with the 4 IOL implanted in the individual eye models for 3 mm pupil diameter,but they were different from each other for 4 and 5 mm pupils,indicating that individual people with different anatomic structures need certain types of IOL to obtain optimal optical performance.This phenomenon was more pronounced for larger pupil.Conclusion The individual eye model based on an individual patient's anatomic parameters should mimic the optical performance of an individual's eye.The type of IOL is varied to obtain optimal optical performance for the optical system of the human eye with different anatomic structures.We should choose an IOL based on the individual eye's structure to obtain optimal retinal image clinically.