| 浊度法定量检测甘露醇注射液细菌内毒素含量 |
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| 引用本文： | 王复馨,雒琪,李军. 浊度法定量检测甘露醇注射液细菌内毒素含量[J]. 医药导报, 2001, 20(9): 583-583 |
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| 作者姓名： | 王复馨 雒琪 李军 |
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| 作者单位： | 山东省立医院 |
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| 摘 要： | 目的：建立动态浊度法定量检测甘露醇注射液中细菌内毒素方法，控制药品质量，减少临床热原反应发生。方法：按中国药典2000年版附录中细菌同毒素检测法及细菌内毒素检测法指导原则的规定，对甘露醇注射液中细菌内毒素定量检测进行可行性研究，结果：甘露醇注射液经4倍释释后可完全消除对鲎试剂与细菌内毒素凝集反应的干扰。结论：应用动态浊度法定量检测甘露醇注射液细菌内毒素含量，结果准确，在实际应用中完全可行。
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| 关 键 词： | 动态浊度法 细菌内毒素 甘露醇注射液 含量测定 |
| 文章编号： | 1004-0781(2001)09-0583-02 |
| 修稿时间： | 2001-03-21 |
Quantitiative Deteciton of Bacterial Endotoxin in Mannitol Injection by Kinetic Turbidimetric Assay |
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| WANG Fu xin,LUO Qi,LI Jun. Quantitiative Deteciton of Bacterial Endotoxin in Mannitol Injection by Kinetic Turbidimetric Assay[J]. Herald of Medicine, 2001, 20(9): 583-583 |
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| Authors: | WANG Fu xin LUO Qi LI Jun |
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| Abstract: | Objective:To establish a quantitative method for detecting bacterial endotoxin in mannitol injection through kinetic turbidimetric assay. Methods:A study of the feasibility of quantitative detection of bacterial endotoxin in mannitol injection was performed, based on the appendix of China pharmacopoeia 2000. Results:Diluting the mannitol injection for 4 times can completely eliminate the interference of the TAL preparations. Conclusion:Quantitative detection of bacterial endotoxin in mannitol injection by kinetic turbidimetric assay is entirely feasible in practice. |
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| Keywords: | Kinetic turbidimetric assay Bacterial endotoxin Mannitol injection |
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