| ~(18)F-FDG PET在新生儿缺氧缺血性脑病中的临床应用 |
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| 引用本文： | 史源,金榕兵,赵锦宁,唐仕芳,李华强,李廷玉. ~(18)F-FDG PET在新生儿缺氧缺血性脑病中的临床应用[J]. 第三军医大学学报, 2010, 32(1) |
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| 作者姓名： | 史源 金榕兵 赵锦宁 唐仕芳 李华强 李廷玉 |
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| 作者单位： | 第三军医大学大坪医院野战外科研究所儿科,重庆,400042;第三军医大学大坪医院野战外科研究所核医学科,重庆,400042;重庆医科大学附属儿童医院儿童保健中心,重庆,400014 |
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| 基金项目： | 重庆市自然科学基金(CSTC2004BB5247)~~ |
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| 摘 要： | 目的对新生儿缺氧缺血性脑病(hypoxic-ischemic encephalopathy,HIE)患儿应用18氟脱氧葡萄糖(18F-FDG)正电子发射断层显像(PET)测定脑葡萄糖代谢,探讨PET测定脑葡萄糖代谢在新生儿HIE中的临床应用价值。方法选择健康足月新生儿9例、早产儿7例和HIE患儿8例,共24例,在注射37 MBq/kg18F-FDG后应用PET测定脑葡萄糖代谢。结果早产儿和健康足月新生儿脑18F-FDG PET显像,其葡萄糖代谢活性区主要在丘脑较高[SUV值分别为(0.71±0.11)、(1.74±0.41)],在大脑皮层较低;足月新生儿大脑皮层摄取的葡萄糖活性较早产儿为高,结构较为清晰;HIE患儿脑存在明显葡萄糖代谢异常,主要表现为:大脑皮层18F-FDG摄取量不一致,如损伤一侧明显低于对侧,或某区域低于其他区域;全脑葡萄糖代谢偏低,尤其是皮层下白质、丘脑、基底节等部位最明显。结论早产儿和健康足月新生儿脑18F-FDG PET显像有自身特点,HIE患儿脑存在明显葡萄糖代谢异常,应用18F-FDG PET测定脑葡萄糖代谢为判断新生儿脑组织损伤程度提供了新的方法。
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| 关 键 词： | PET 婴儿 新生 脑缺氧 脑缺血 |
Cerebral glucose metabolism in neonatal hypoxic-ischemic encephalopathy:a study by (18)F-nuorodeoxyglucose positron emission tomography |
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| Shi Yuan,Jin Rongbing,Zhao Jinning,Tang ShiQing,Li Huaqiang,Li Tingyu. Cerebral glucose metabolism in neonatal hypoxic-ischemic encephalopathy:a study by (18)F-nuorodeoxyglucose positron emission tomography[J]. Acta Academiae Medicinae Militaris Tertiae, 2010, 32(1) |
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| Authors: | Shi Yuan Jin Rongbing Zhao Jinning Tang ShiQing Li Huaqiang Li Tingyu |
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| Affiliation: | 1Department of Pediatrics;2Department of Nuclear Medicine;Institute of Surgery Research;Daping Hospital;Third Military Medical University;Chongqing;400042;3Center of Child Health Care;Children's Hospital;Chongqing Medical University;400014;China |
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| Abstract: | Objective To study the clinical value of cerebral glucose metabolism measured by 18F-fluorodeoxyglucose positron emission tomography(18F-FDG PET) in neonatal hypoxic-ischemic encephalopathy(HIE).Methods Totally 24 neonates,including 9 full-term neonates,7 preterm newborn infants,and 8 neonates in our department from Jan.2004 to Dec.2006 were subjected.All of them received 18F-FDG PET imaging after the informed consent was signed by their parents and our study was approved by the Ethics Committee of Third Mi... |
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| Keywords: | positron emission tomography infant newborn cerebral ischemia cerebral hypoxia |
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