| 头孢拉定分散片的生物利用度研究 |
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| 引用本文： | 傅民,葛庆华,周臻,王浩,何广安. 头孢拉定分散片的生物利用度研究[J]. 中国医药工业杂志, 2001, 32(1): 17-19 |
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| 作者姓名： | 傅民 葛庆华 周臻 王浩 何广安 |
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| 作者单位： | 药物制剂国家工程研究中心上海现代生物利用度检测所, |
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| 摘 要： | 对头孢拉定分散片(1)和头孢拉定胶囊(2)进行人体生物等效性评价。10名健康男性受试者随机交叉单剂量口服两种剂型后(各500mg),以HPLC-UV测血药浓度。1和2的AUC0→T(n)分别为26.66±6.31和25.62±6.01μg
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| 关 键 词： | 头孢拉定分散片 生物利用度 HPLC |
| 文章编号： | 1001-8255(2001)01-0017-03 |
| 修稿时间： | 1999-03-23 |
Relative Bioavailabilityof Cefradine Dispersible Tablets |
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| FU Min,GE Qing-hua,ZHOU Zhen,WANG Hao,HE Guang-An. Relative Bioavailabilityof Cefradine Dispersible Tablets[J]. , 2001, 32(1): 17-19 |
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| Authors: | FU Min GE Qing-hua ZHOU Zhen WANG Hao HE Guang-An |
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| Abstract: | The pharmacokinetics and relative bioavailability of cefradine dispersible tablets (1) were investigated at oral dose of 500 mg in ten healthy volunteers. Drug concentrations in plasma were assayed by HPLC. The areas under the drug concentration-time curves (AUC0→T(n)) were 26.66±6.31 and 25.62±6.01 μg*ml-1*h, the mean residence time (MRT) was 1.44±0.19 and 1.66±0.27 h, and the biological half life (t1/2) was 1.07±0.28 and 0.97±0.14 h for 1 and cefradine capsules (2), respectively. The relative bioavailability of 1 was 105.0±14.6%, compared with 2. The results showed that the two dosage forms were bioequivalent. |
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| Keywords: | cefradine dispersible tablets relative bioavailability HP |
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