声触诊组织定量技术在慢性肾病中的初步应用

目的 探讨声触诊组织定量(VTQ)技术评估慢性肾脏疾病(CKD)肾组织纤维化程度的价值。方法 对45例经肾组织活检证实的CKD患者进行VTQ以及常规超声检查。分析VTQ以及常规超声指标与患者临床及病理指标(CKD分期、肾小球硬化指数、肾小管萎缩面积以及肾间质纤维化面积)之间的相关性。结果 肾皮质SWV值CKD 1期为(2.74±0.57)cm/s, CKD 2期为(2.30±0.27)cm/s, CKD 3期为(2.85±0.26)cm/s, CKD 4期为(2.60±0.40)cm/s。统计分析显示肾皮质SWV值与CKD分期及病理指标间无相关性。讨论 VTQ技术可以测定的肾脏皮质的SWV值;但肾脏皮质SWV值与CKD分期及肾组织纤维化指标间无相关性。

Preliminary application of virtual touch tissue quantification technique in chronic kidney disease

Objective To explore the value of virtual touch tissue quantification (VTQ) in assessment of renal tissue fibrosis in chronic kidney disease (CKD) patients. Methods Totally 45 patients with CKD confirmed by renal biopsies underwent conventional ultrasound and VTQ to measure their left renal cortical shear wave velocity (SWV) values, as well as renal length, cortical thickness, interlobar arterial resistive index. Correlation of SWV/conventional ultrasound indicators and patient's CKD stage/fibrosis indicators on histopathology were analyzed. Results The median SWV was (2.74±0.57)cm/s, (2.30±0.27)cm/s, (2.85±0.26)cm/s and (2.60±0.40)cm/s for stage 1, 2, 3 and 4 in CKD patients respectively. And Spearman correlation analysis showed that SWV value had no correlation to any histopathological indicators of tissue fibrosis. Conclusion VTQ technique can assess the tissue stiffness of CKD kidneys by measuring cortical SWV values. However, SWV does not show significant correlations to CKD stage and fibrosis indicators.