CDK4在胃癌中的表达及临床意义

目的研究CDK4在胃癌组织中的表达与临床病理特征之间的关系。方法采用免疫组化方法检测CDK4在70例胃癌组织及部分相应癌旁组织中的表达,结合患者的性别、年龄、肿瘤大小、部位、分化程度、Borrmann分型、浸润深度、淋巴结转移和TNM分期等临床病理参数进行综合分析。结果胃癌组织和癌旁组织中的CDK4蛋白阳性表达分别为65.71%、18.75%,差异有统计学意义(P0.05)。CDK4在低分化组阳性表达率为78.05%(32/41),中高分化组阳性表达率为48.28%(14/29),两组间比较差异有统计学差异(P0.05,χ2=6.693);CDK4在无淋巴结转移组中阳性表达率为44.83%(13/29),有淋巴结转移组中阳性表达率为80.49%(33/41),两者间比较有显著统计学差异(P0.01,χ2=9.587);CDK4在Ⅰ+Ⅱ期阳性表达率为53.13%(17/32),Ⅲ+Ⅳ期组阳性表达率为76.32%(29/38),两组间比较差异有统计学差异(P0.05,χ2=4.147);CDK4蛋白阳性表达与患者的性别、年龄、肿瘤大小、部位、Borrmann分型、浸润深度均无明显相关(P0.05)。结论 CDK4在胃癌组织中存在着过表达,在评估胃癌的发生、发展中有一定的临床价值。CDK4表达水平与肿瘤组织分化程度、淋巴结有无转移、TNM分期有关。

Expression and clinical significance of CDK4 in gastric cancer

Objective This study was designed to delineate the expression and significance of CDK4 in gastric cancer. Methods The expressions of CDK4 protein were detected by immunohischemistry in 70 cases of gastric cancer tissues and matched partly adjacent tissues. The levels of the expression were analyzed com-bining with clinicopathological parameters of the patients including age, gender, tumor diameter, site, differen-tiation, Borrmann type, infiltration depth, lymph node metastasis and TNM stage. Results In gastric cancer and its partly adjacent tissues, CDK4 was positive in 46 cases （65.71%） and 6 cases （18.75%） respectively, the difference was statistically significant （P〈0.05）. In the poorly differentiated group and the well-moderately differentiated group, CDK4 was positive in 32 cases （78.05%） and 14 cases （48.28%）, respectively （P〈0.05）. In non-lymph node metastasis group and the lymph node metastasis group, the CDK4 was positive in 13 cases （44.83%） and 33 cases （80.49%）, respectively （P〈0.05）. According to TNM staging, CDK4 was positive in 17 cases （53.13%） in stageⅠ＋Ⅱgroup, and 29 cases （76.32%） in stageⅢ＋Ⅳgroup, respectively （P〈0.05）. The expression of CDK4 was not associated with patient′s gender, age, tumor size, location, Borrmann type and infiltration depth （P〉0.05）. Conclusions Over-expression of CDK4 exists in gastric cancer, and there is a good relationship between expression of CDK4 and tumor differentiation,lymph node metastasis, and TNM stage. The over-expression of CDK4 in gastric cancer is of great clinical value in evaluating the development of gastric cancer.