AT1R基因A1166C多态性与新疆维吾尔族人群原发性高血压的关系

目的：探讨血管紧张素Ⅱ1型受体(AT1R)基因A1166C多态性与维吾尔族人群原发性高血压
(EH)的关系，阐述AT1R基因A1166C在EH中的作用机制。方法：收集EH组167例、对照组469例、共
636例维吾尔族人群血液样本，采用聚合酶链式反应-限制性片段长度多态性技术（PCR-RFLP）对AT1R基因A1166C进行多态性检测，分析AA、AC和CC 3种基因型以及该位点A、C不同等位基因频率在EH组和对照组中的分布。结果：EH组AC+CC基因型和C等位基因频率明显高于对照
组，差异有统计学意义（χ2=10.179 ，P=0.001）；AC+CC基因型人群患EH的危险度是AA基因型人群的1.6倍（OR=1.612，95%CI:1.191~2.183）。结论：AT1R基因A1166C多态性与维吾尔族EH的发病可能存在一定关联。
［关键词］［中图分类号］

Association between AT1R gene A1166C polymorphism and essential hypertension of Xinjiang Uygur nationality

Objective To investigate the association between angiotensinⅡtype 1receptor(AT1R)gene A1166C polymorphism and essential hypertension(EH)in Uygur nationality and to clarify the action mechanism of AT1R gene A1166Cin the occurrence of EH.Methods 636cases of Uyghur population blood samples including 167cases of EH group and 469cases of control group were collected.Then polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP)method was adopted to examine the AT1Rgene A1166Cpolymorphism.The distribution of AA,AC and CC genotypes and the different frequencies of the points A,C in EH and control groups were analyzed.Results The AC+CC genotype and C allele frequency in EH group were significantly higher than those in control group,the difference was statistically significant(χ2=10.179,P=0.001);the risk of EH of the people with AC+CC genotypes was 1.6(OR=1.612,95%CL:1.191-2.183)times than that of the people with AA genotype.Conclusion There might be some relationship between AT1R gene A1166C polymorphism and the EH in Uighur population.