烯丙雌醇在不同时期用药治疗复发性自然流产的效果观察

目的：分析烯丙雌醇在不同时期用药治疗复发性自然流产的临床效果。方法选择172例复发性自然流产患者为研究对象，根据用药不同分为两组。对照组43例给予黄体酮治疗，观察组129例给予烯丙雌醇治疗。观察组又根据用药时间不同分为3组，各43例。观察A组、观察B组及观察 C组用药时间分别为排卵后、受孕后2周及受孕后3周。比较各组治疗效果及足月分娩率。结果观察A组总有效率高于对照组和观察C组（ P ＜0．01）；观察组足月分娩率高于对照组（ P＜0．01），其中观察A组足月分娩率高于观察B组（ P ＜0．05）和观察C组（ P ＜0．01）。结论烯丙雌醇治疗复发性自然流产最佳用药时期为患者排卵后，可提高临床治疗效果，足月分娩率明显提升。

C linical observation of allylestrenol drug treatment of recurrent spontaneous abortion during different periods

Objective To analyze the clinical efficacy of allylestrenol treatment of recurrent spontaneous abortion during differ -ent periods .Mte hods Clinal data of 172 patients with recurrent spontaneous abortion were analyzed and the patients were divided into control group （ n =43 ） and the observation group （ n =129 ） according to different dosages .The control group was given ogesterone treatment,and the observation group was divided into three subgroups （ n =43,each）according to different drug treatment periods and received allylestrenol treatment .The drug giving periods of subgroup A , B, and C were after ovulation ,two weeks after conception ,three weeks after conception respectively .Clinical efficacy and term delivery rates of each group were compared .Results The total effective rate of observation subgroup A was higher than that of subgroup C （ P 〈0.01）and term delivery rates of observation group were higher than that of control group（ P 〈0.01）,term delivery rate of observation subgroup A was higher than that of subgroup B （ P 〈0.05）and C（ P 〈0.01）.Conclusion The best periods of allylestrenol treatment of recurrent spontaneous abortion is after ovulation ,which can improve clinical treatment outcomes and the success rate of term delivery .