MTAP基因多态性rs3802392与缺血性卒中的关系 |
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引用本文: | 刘波,牛文亮. MTAP基因多态性rs3802392与缺血性卒中的关系[J]. 包头医学院学报, 2014, 0(4): 41-43 |
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作者姓名: | 刘波 牛文亮 |
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作者单位: | 刘波 (包头医学院第一附属医院神经内科,内蒙古 包头,014010); 牛文亮 (包头医学院第一附属医院神经内科,内蒙古 包头,014010); |
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基金项目: | 内蒙古自治区高等学校科学研究项目(项目编号:NJZY11181) |
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摘 要: | 目的:探讨甲硫腺苷磷酸化酶( Methylthioadenonine Phosphorylase,MTAP)基因多态性rs3802392与缺血性卒中的相关性。方法:采用聚合酶链式反应和限制性片段长度多态性( PCR-RFLP )方法对273例缺血性卒中患者和344例健康人的 rs3802392进行基因分型,并用 Logistic 回归方法分析其与缺血性卒中的关系。结果:MTAP 基因rs3802392基因型和等位基因频率在病例组和对照组的分布差异有统计学意义,MTAP基因rs3802392位点GA+GG基因型是缺血性卒中发病的独立危险因素。结论:MTAP基因rs3802392可能在缺血性卒中的发病中起一定作用。
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关 键 词: | 甲硫腺苷磷酸化酶 单核苷酸多态性 缺血性卒中 Single nucleotide polymorphism( SNP) |
ReIationship between PoIymorphisms of MethyIthioadenosine PhosphoryIase Gene and Ischemic Stroke |
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Affiliation: | LIU Bo, NIU WenIiang (Department of Neurology, the First Affiliated Hospital of Baotou Medical College, Baotou 014030, China) |
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Abstract: | ObjectiVe:To inVestigate the relationship between single nucleotide polymorphism( SNP)rs3802392 in methyl-thioadenosine phosphorylase( MTAP)gene and ischemic stroke. Methods:SNP rs3802392 was genotyped among 273 patients with ischemic stroke and 344 normals as control group by polymorphism chain reaction( PCR)and restriction fragment length pol-ymorphism( RFLP)method. And the association of rs3802392 with ischemic stroke was analyzed using Logistic regression. Re-suIts:The significant differences in allele and genotype frequencies were detected between the case group and the control group, and GA+GG genotype was the independent risk factor for ischemic stroke. ConcIusion:SNP rs3802392 in MTAP gene may play a role in the deVelopment of ischemic stroke. |
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Keywords: | Methylthioadenosine phosphorylase Ischemic stroke |
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